Magnesium Versus High Dose Fentanyl in Endotracheal Intubation

National Cancer Institute, Egypt160 enrolled

Overview

this study is designed to assess the efficacy of MgSO4 versus high dose fentanyl compared to conventional anesthesia in attenuating stress response to intubation

to assess the effect of MgSO4 combined with fentanyl compared to high dose fentanyl in attenuating stress response in cancer patients undergoing surgeries under general anesthesia requiring endotracheal intubation

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

160

Conditions

Stress Response

Interventions

Magnesium sulfate- FentanylDRUG

drug administration before intubation

Fentanyl 4Mcg/kgDRUG

drug administration with induction of anesthesia

Fentanyl 2Mcg/kgDRUG

drug administration with induction of anesthesia

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Cancer patients undergoing surgery under general anesthesia requiring endotracheal intubation * ASA I II * 18 to 60 Exclusion Criteria: * allergy to any of the used drugs * renal or hepatic impairment * hypertensive patients, patients with cardiovascular or cerebrovascular diseases

Locations (1)

Walaa Y Elsabeeny

Cairo, Egypt

Outcomes

Primary Outcomes

heart rate values

changes in heart rate values after intubation

Time frame: 5 minutes

Secondary Outcomes

blood pressure

mean arterial blood pressure values

Time frame: 5 minutes

coughing during intubation

Time frame: lntubation time

Data from ClinicalTrials.gov

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