A Study Evaluating the Long-term Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis (CF) Particpants 6 Years and Older and F/MF Genotypes

Absolute Change From Parent Study Baseline in Sweat Chloride (SwCl)

Sweat samples were collected using an approved collection device.

Time frame: From Parent Study Baseline to Week 96

Absolute Change From Parent Study Baseline in Lung Clearance Index 2.5 (LCI2.5)

The LCI2.5 index is the number of lung turnovers required to reduce the end tidal inert gas concentration to 1/40th of its starting values and is calculated by dividing the sum of exhaled tidal breaths (cumulative exhaled volume (CEV)) by simultaneously measured functional residual capacity (FRC). An LCI of 7.5 and below is normal; values greater than 7.5 are abnormal. LCI is able to detect abnormalities in lung function earlier than more traditional modalities such as spirometry.

Time frame: From Parent Study Baseline to Week 96