Breath Analysis for SARS-CoV-2 in Infected and Healthy Subjects

Klinikum Bayreuth GmbH200 enrolled

Overview

Recently published studies could demonstrate that detection of specific biomarkers in breath could be applied for the diagnosis of SARS-CoV-2.

In this study we want to address the sensitivity and specificity of breath analysis by MCC-IMS in the context of SARS-CoV-2 detection from PCR- proven infected and non-infected subjects. Therefore nasal breath will be aspirated for 10 seconds during normal respiration by a foam cuffed oxygen catheter connected via a 0.22μm filter and a line into the MCC-IMS and directly analyzed without any pre-analytic procedures. The during the proof-of-concept study derived significant peaks for volatile organic compounds will be used for discrimination in a point-of-care approach.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

SARS-CoV-2 Infection

Interventions

Multicapillary column coupled ion mobility spectrometryDIAGNOSTIC_TEST

sampling of nasal air via a foam cuffed oxygen catheter

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: hospital admission staff members Exclusion Criteria: too sick to comply with study procedures

Locations (1)

Klinikum Bayreuth/ Bayreuth General Hospital

Bayreuth, Germany

RECRUITING

Outcomes

Primary Outcomes

correct classification of SARS-CoV-2 infected and not infected subjects

Time frame: 6 months

Data from ClinicalTrials.gov

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