Timing of Rocuronium After Induction With Propofol on Temporal Summation of Pain

Wonkwang University Hospital100 enrolled

Overview

Temporal summation of pain, which is defined as the perception of increasingly greater pain evoked by repetitive painful stimuli, is highly variable between individuals. This study aimed to determine the impact of the timing of rocuronium after induction with propofol on temporal summation of pain in gynecologic laparoscopic surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

100

Conditions

Gynecological Disorder

Interventions

The difference of the timing of rocuronium administration after propofol injectionOTHER

The difference of the timing was rocuronium was administered immediately after propofol injection or when BIS score became below 60 after propofol administration.

Eligibility

Sex: FEMALEMin age: 19 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Elective gynecologic laparoscopic surgery * American Society of Anesthesiologists' physical status class) I-II Exclusion Criteria: * Menopause (to exclude the hormonal effect on pain) * Patients who had muscular, cardiovascular, hepatic or kidney disorders and patients with a history of medication who would affect muscle relaxants were excluded from this study. * Patients with difficult venous access on forearm, a known allergy to propofol or rocuronium, chronic pain, pregnancy, and those who had received analgesics or sedatives within the previous 24 hours, were excluded from the study.

Locations (1)

WonwangUH

Iksan, Jeollabuk-do, South Korea

Outcomes

Primary Outcomes

the grade of rocuronium induced withdrawal movement.

withdrawal movements were graded by the investigator according to the following scale: 1. \- no pain (no response); 2. \- mild pain (movement at wrist only); 3. \- moderate pain (movement involving the arm only with elbow or shoulder); 4. \- severe pain (generalized response or movement in more than one extremity

Time frame: during anesthesia induction

Secondary Outcomes

visual analog scale (VAS) for injection pain

check VAS for pain after propofol administration. visual analog scale with 100 mm for pain after surgery. 0 = no pain, 100 = the worst pain

Time frame: during anesthesia induction

VAS for pain

check VAS with 100 mm for pain after surgery. 0 = no pain, 100 = the worst pain

Time frame: at 1 hour, 24 hours and 48 hours

Patient controlled analgesia (PCA) Opioid consumption

check the volume of PCA Opioid consumption (ml) (PCA) pump containing fentanyl (800 ug), ketorolac (150 mg), and ramosetron (0.6 mg) in a total volume of 150 mL of saline was set to deliver a basal infusion of 2 mL/h and bolus doses of 0.5 mL, with a 15-min lockout period for postoperative analgesia.

Time frame: at 24 and 48 hours

Data from ClinicalTrials.gov

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