There are few studies on the role played by emotions in transient global amnesia (TGA), in particular with regard to their impact on the functioning of memory. The study investigators wish to better understand the link between episodic memory, emotional state and psychogenic factors during TGA. It would be interesting to see if the patients suffering from TGA triggered by a psychological shock process emotional information differently from those whose TGA was triggered by an "organic" shock (physical effort, trauma, etc.). Finally, amnesic stroke is a good model for better understanding the function of the hippocampus, in particular of the CA1 region, in episodic memory.
Study Type
OBSERVATIONAL
Enrollment
2
The subject is placed in supine position, the head immobilized in a headrest. The imaging sequence begins with a scout view (viewing angle 90 °, 120 kV, 20 mA), then an X-ray scan is performed for the attenuation correction (120 kV, 5 mAs per slice, pitch 0.531, collimation 40 mm , FOV 70) and diagnostic CT scan (120 kV, 100-250 mA: auto mA, pitch 0.531, 40 MM, DFOV 25, ASIR 60%, thickness 1.25 mm). Finally, the positron emission tomography is acquired: static in 3D mode for 15 minutes, 30 minutes after the injection of 18 FDG, the axial field of view is 25, the matrix in 256 x 256, OSEM reconstruction 6 iterations 24 subsets, attenuation correction, diffused, and PSF. Gaussian filter, cutoff frequency of 4. Obtaining forty-seven contiguous sections of 3.26 mm thick.
CHU de Nimes
Nîmes, France
Storage and retrieval capacities of information with a strong emotional valence in patients compared to healthy controls
International Affective Picture System (IAPS): number of correctly memorized images of each type of emotional content (15 positive, 15 negative and 15 neutral).
Time frame: Day 0
Ability to judge the degree of activation and emotional value associated with images
Self Assessment Manikin (SAM)
Time frame: Day 0
Change in storage and retrieval capacities of information with a strong emotional valence in patients from baseline
International Affective Picture System (IAPS): number of correctly memorized images of each type of emotional content (15 positive, 15 negative and 15 neutral).
Time frame: Day 3
Change in storage and retrieval capacities of information with a strong emotional valence in patients from baseline
International Affective Picture System (IAPS): number of correctly memorized images of each type of emotional content (15 positive, 15 negative and 15 neutral).
Time frame: Month 3
Classification of event triggering transient global amnesia
Psychological/physiological
Time frame: Day 0
Anxiety
Hamilton Scale: where score = 7 is absence of depression; 8-15 is minor depression and 16 or more is severe depression
Time frame: Day 0
Depression
Beck Depression Scale
Time frame: Day 0
Mood
Befindlichkeits Skala Mood Scale
Time frame: Day 0
C-score of the Groupe de REflexion pour l'Evaluation des Fonctions Exécutives (GREFEX) version of Stroop Test between patients and healthy control
Stroop Test
Time frame: Day 0
Repeatable Battery for the Assessment of Neuropsychological Status between patients and healthy control
Repeatable Battery for the Assessment of Neuropsychological Status: 10 subtests combined into 5 index scores and 1 total score.
Time frame: Day 0
Identification of hypometablic zones by PET compared to age- and sex-matched controls
Visual analysis of hippocampus and other topographies (Z-score); Statistical Parametric Mapping 12
Time frame: Day 0
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