Prolonged Cardiopulmonary Bypass Time as Predictive Factor for in Hospital Infection

University Hospital, Basel, Switzerland7,064 enrolled

Overview

This study is to analyse the demographics and microbiological factors concerning patients undergoing cardio surgical intervention using CPB complicated with bloodstream infection (BSI) postoperatively.

Infectious complications after cardiovascular surgery, especially in operations that use cardiopulmonary bypass (CPB), is associated with significant morbidity and increase in peri-operative mortality. Prolonged CPB usage could be predictive for early bloodstream infection following cardia surgery. This study is to analyse the demographics and microbiological factors concerning patients undergoing cardio surgical intervention using CPB complicated with bloodstream infection (BSI) postoperatively.

Study Type

OBSERVATIONAL

Enrollment

7,064

Conditions

Bloodstream Infection (BSI)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * adult patients undergoing cardiac surgery Exclusion Criteria: * patients having active or previous endocarditis * patients whose causative microorganism of postoperative BSI was identical to that isolated from preoperative or intraoperative samples * patients with common skin colonized microorganisms, such as coagulase-negative Staphylococci, Viridans group Streptococci, Corynebacterium species, Bacillus species, Propionibacterium species, and Aerococcus species or Micrococcus species, which were isolated from only a single blood sample and without evidence of clinical sepsis, because contamination was considered.

Locations (1)

Klinik für Herzchirurgie, University Hospital Basel

Basel, Switzerland

Outcomes

Primary Outcomes

Incidence of bloodstream infection (BSI) in postoperative period (clinical evidence of sepsis with laboratory-confirmed bacteraemia from blood sample)

Time frame: within 7 days after a cardiovascular surgery

Extracorporeal circulation time during surgery (minutes)

Time frame: one time assessment at baseline

In-hospital mortality (number) for patients with BSI vs those without BSI after a cardiovascular surgery

In-hospital mortality is defined as death before discharge

Time frame: during hospital stay (usually up to 4 weeks)

Surgical intervention rate (Incidence of cardiovascular re-operation) during the initial hospital stay (number)

Surgical intervention rate (Incidence of cardiovascular re-operation) during the initial hospital stay

Time frame: during hospital stay (usually up to 4 weeks)

Secondary Outcomes

Incidence of cardiovascular events (stroke, myocardial infarction) during hospitalization

Incidence of cardiovascular events during hospitalization

Time frame: during hospital stay (usually up to 4 weeks)

Incidence of cardiovascular events (stroke, myocardial infarction) during follow-up

Time frame: after hospital discharge until follow- up assessment (up to 10 years)

Data from ClinicalTrials.gov

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