Children supported by Extra-Corporeal Membrane Oxygenation (ECMO) present a high risk of neurological complications and cerebral autoregulation (CA) impairment may be a risk factor. The first objective is to investigate the association between CA impairments and neurological outcome assessed by the onset of an ANE. The secondary objective is to study the underlying mechanisms influencing CA.
Patients : All children treated by ECMO in the 4 PICUs involved in the study Measurements : A correlation coefficient between the variations of regional cerebral oxygen saturation (rScO2) as a surrogate of cerebral blood flow and the variations of arterial blood pressure (ABP) is calculated as an index of autoregulation (cerebral oxygenation index (COx), ICM+ software®). CA is monitored either on left (COxl) or both sides. A COx \> 0.3 is considered as critical. Neurological outcome is assessed by the onset of an acute neurologic event (ANE) during the ECMO run.
Study Type
OBSERVATIONAL
Enrollment
132
CHU de Nantes
Nantes, France
AP-HP Trousseau Hospital
Paris, France
AP-HP Necker Hospital
Paris, France
Giannina Gaslini Institute (IRCCS)
Genova, Italy
Association between CA metrics and neurological outcome
Association between the percentage of time spent in critical region of CA and the onset of an acute neurological event (stroke and/or seizures and/or brain death) or not.
Time frame: 1 year
Analysis of the influence of PCO2 on CA
Association between PCO2 value (mmHg) and COX value
Time frame: 1 year
Analysis of the influence of PCO2 on CA
Influence of ECMO settings on CA
Time frame: 1 year
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