A First in Human Study to Evaluate the Safety of Infusion of MNV-BM-PLC (Autologous CD34+ Cells Enriched With Placenta Derived Allogeneic Mitochondria) in Patients With Primary Mitochondrial Diseases Associated With Mitochondrial DNA Mutation or Deletion

Inclusion Criteria: * Molecular diagnosis of primary mitochondrial disease * Age between 4 years and up to 18 years, with a minimum body weight of 20 (+/-1) kilogram on the day of screening visit. * Performance score: Karnofsky ≥40 (or equivalent in children younger than 16 years old. * Patients or Patient's parents or legal guardian (where applicable) has a good understanding of the study and nature of the procedure and is willing and able to provide written informed consent prior to participation in any study-related procedures. * Medical ability to undergo the study procedures safely, as determined by the investigator. Exclusion Criteria * Positive test for pathogenic agents . * Inability to undergo leukapheresis, as determined by the investigator. * Chronic severe infection or any other disease or condition that may risk the patient or interfere with the ability to interpret the study results. * Known history of malignancy. * Patient has been treated within the last one year prior to IP treatment with a different cell therapy. * Patient has participated in another interventional clinical study and/or received other experimental medication outside of a clinical study within 1 month prior the day of Investigation product (IP) treatment visit. * A pregnant or lactating woman or a woman who plans to become pregnant during the study. In addition, any woman of childbearing potential (not sterile or postmenopausal), who is unwilling to adhere to the use highly effective contraception method for the duration of the study * In the opinion of the Investigator, the patient is unsuitable for participating in the study due to safety concerns.