Immune Tolerance Dysfunction in Pregnancy Due to Ambient Air Pollution Exposure

Stanford University400 enrolled

Overview

The purpose of this project is to study the effects of air pollution toxicants on pregnant mothers' immune health during and after pregnancy. Using already collected samples, this study proposes to evaluate changes in immune function in response to air pollution with the use of innovative technologies, to identify the drivers of immune dysfunction and potential modifiable factors, and to determine how these immune findings are associated with pollution exposure and outcomes of disease.

Study Type

OBSERVATIONAL

Enrollment

400

Conditions

Air Pollution Pregnancy

Interventions

There is no interventionOTHER

There is no intervention

Eligibility

Sex: FEMALEMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Pregnant women: at 18-25 weeks gestation at time of eligibility screening and baseline visit Exclusion Criteria: * Having smoked more than 50 cigarettes during pregnancy * A history of autoimmune diseases, HIV or cancer

Locations (1)

Sean N. Parker Center for Allergy & Asthma Research at Stanford University

Palo Alto, California, United States

Outcomes

Primary Outcomes

Difference in immune cell subset identity and function in pregnant vs. non pregnant women exposed to high vs. low pollution over time

Time frame: 3 years

Identify the epigenetic molecular mechanisms driving immune dysfunction in pregnancy vs. no pregnancy with high vs. low PM2.5 exposure over time

Time frame: 3 years

Map T cell receptor diversity to immune dysfunction in pregnancy vs non pregnancy with high vs. low PM2.5 exposure over time

Time frame: 3 years

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.