Contribution of L-Tyrosine to Recovery From Operational Strain on Return From External Operation

Direction Centrale du Service de Santé des Armées116 enrolled

Overview

Operational conditions amplify soldier's constraints and stress factors, upsetting individual and collective adaptive landmarks. The soldier's resistance is strained by the high intensity of stressors, by the long duration of exposure and by their cumulative effect. This may lead to a state of "operational strain" that refers to chronic stress and the allostatic load imposed by operational constraint. The investigators believe that operational strain could manifest itself by a kind of accelerated aging of the organism due to the increased allostatic load without sufficient resource restoration (neurotransmitter precursors, partial and repeated sleep deprivation, etc.). This aging mechanism would be reversible after a sufficient period of resource restoration (sleep, physical activity, adapted diet, etc.).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

116

Conditions

Stress, Psychological

Interventions

A blood sample will be collected before during and after the treatment.

L-Tyrosine 500 MgDRUG

The participants will be administered 4 capsules of L-Tyrosine 500 mg per oral route daily over 1 month.

Psychological questionnairesBEHAVIORAL

The participants will fill in several psychological questionnaires before, during and after treatment administration: * Life Event Checklist * Moral injury * Posttraumatic Checklist * Burnout Assessment Tool * State-Trait Anger Expression Inventory-2 * Ruminative Response Scale - Reconsidered * Deployment Risk and Resilience Inventory-2 * Questionnaire about tobacco use

PhotoplethysmographyDEVICE

Photoplethysmography recording will be performed before during and after the treatment.

PlaceboDRUG

The participants will be administered 4 capsules of Lactose 500 mg (placebo) per oral route daily over 1 month.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * From 18 to 65 years of age Exclusion Criteria: * Tyrosine intake within the previous 15 days * History of neurological or psychiatric disorder * History of nephrological or endocrine disorder or liver failure * Hereditary tyrosinemia

Locations (1)

Institut de Recherche Biomédicale des Armées

Brétigny-sur-Orge, France

Outcomes

Primary Outcomes

Difference between the change in Burnout Assessment Tool (BAT) score following 1-month treatment in each arm

The Burnout Assessment Tool (BAT) is used to assess burn-out risk. The score ranges from 1 to 5, with higher scores indicating a higher risk of burn-out.