This study will be available to any participant who has received or is currently receiving belantamab mafodotin treatment through either a clinical trial, an access program, or a physician prescription. Participants do not need to be on active treatment. The purpose of this study is to gain a more complete understanding of the pathophysiology of the corneal events seen in some participants with relapsed/refractory multiple myeloma (RRMM) treated with belantamab mafodotin. A superficial corneal epithelial tissue specimen will be obtained by performing impression cytology (IC) or superficial keratectomy (SK) procedure in participants treated with belantamab mafodotin. The procedure will only be performed in one eye, most affected by the corneal epithelial changes. This specimen will undergo pathologic examination and composition analysis.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
16
Belantamab mafodotin is a first-in-class immunoconjugate that targets B cell maturation antigen (BCMA), which is highly expressed on malignant plasma cells.
GSK Investigational Site
San Francisco, California, United States
GSK Investigational Site
Atlanta, Georgia, United States
GSK Investigational Site
Westwood, Kansas, United States
GSK Investigational Site
Baltimore, Maryland, United States
GSK Investigational Site
New York, New York, United States
GSK Investigational Site
Chapel Hill, North Carolina, United States
Number of Participants With Abnormality in Composition of Corneal Epithelium After Administration of Belantamab Mafodotin
Corneal tissue samples were collected to evaluate the composition of microcyst-like epithelium observed in participants treated with belantamab mafodotin.
Time frame: Up to approximately 23 months
Number of Participants With Abnormality in Pathologic Characteristics After Administration of Belantamab Mafodotin
Corneal tissue samples were collected to evaluate pathologic characteristics observed in participants treated with belantamab mafodotin.
Time frame: Up to approximately 23 months
Number of Participants With Imaging Data Showing Histopathologic Findings
The eye was visualized using a slit-lamp microscope in a procedure room.
Time frame: Up to approximately 23 months
Number of Participants With Adverse Events (AEs)
An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of a study intervention, whether or not considered related to the study intervention.
Time frame: Up to approximately 23 months
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