Little is currently known about the immediate and long-term effect of COVID-19 on lung ventilation (delivery of air to the lungs) and lung perfusion (delivery of blood to the lungs). Some people who survive COVID-19 may have lung ventilation and/or perfusion injury that persists following COVID-19 recovery. This lung injury may be related to inflammation in the lung, breathlessness, exercise limitation and reduced quality of life. Therefore, towards the goal of understanding the effects of COVID-19 on lung health, the purpose of this study is to characterize and understand the clinical relevance of COVID-19 related lung ventilation and perfusion injury and associated inflammatory status, ≤4 weeks and 6-months following COVID-19 recovery in an asthmatic and healthy population. To do this, an asthmatic and healthy population who have, and have not, been previously diagnosed with COVID-19 will be studied.
Study Type
OBSERVATIONAL
Enrollment
42
At visits 1 and 2, ventilation will be assessed by 99mTc Technegas SPECT ventilation scan and perfusion will be assessed by 99mTc Macroaggregated Albumin SPECT perfusion scan.
At visits 1 and 2, quality of life will be evaluated using the St. George's Respiratory Questionnaire (SGRQ).
At visits 1 and 2, dyspnea will be evaluated using the mMRC (Modified Medical Research Council) Dyspnea Scale.
At visits 1 and 2, exercise capacity will be evaluated using the six-minute walk test (6MWT).
At visits 1 and 2, spirometry will be performed to quantify the forced expiratory volume in one second (FEV1), the forced vital capacity (FVC) and FEV1/FVC.
At visits 1 and 2, plethysmography and the diffusing capacity of the lung for carbon monoxide (DLCO) will be performed.
At visits 1 and 2, airwave oscillometry will be performed to obtain resistance (R) and reactance (X) at 5 Hz (R5) and 19 Hz (R19). The resonance frequency (fres), area above the reactance curve (AX) and the heterogeneity of obstruction (R5-19) will be derived from R and X.
St. Joseph's Healthcare Hamilton
Hamilton, Ontario, Canada
Short-term difference in ventilation defect percent assessed by ventilation SPECT-CT - healthy
The short-term difference in lung ventilation between healthyCOVID-19+ and healthyCOVID-19- participants
Time frame: ≤4-weeks post COVID-19 recovery (Visit 1)
Short-term difference in perfusion defect percent assessed by perfusion SPECT-CT - healthy
The short-term difference in lung perfusion between healthyCOVID-19+ and healthyCOVID-19- participants
Time frame: ≤4-weeks post COVID-19 recovery (Visit 1)
Short-term difference in lung ventilation/perfusion mismatch assessed by ventilation/perfusion SPECT-CT - healthy
The short-term difference in lung ventilation/perfusion mismatch between healthyCOVID-19+ and healthyCOVID-19- participants
Time frame: ≤4-weeks post COVID-19 recovery (Visit 1)
Long-term difference in ventilation defect percent assessed by ventilation SPECT-CT - healthy
The long-term difference in lung ventilation between healthyCOVID-19+ and healthyCOVID-19- participants
Time frame: 6-months post COVID-19 recovery (Visit 2)
Long-term difference in perfusion defect percent assessed by perfusion SPECT-CT - healthy
The long-term difference in lung perfusion between healthyCOVID-19+ and healthyCOVID-19- participants
Time frame: 6-months post COVID-19 recovery (Visit 2)
Long-term difference in ventilation/perfusion mismatch assessed by ventilation/perfusion SPECT-CT - healthy
The long-term difference in lung ventilation/perfusion mismatch between healthyCOVID-19+ and healthyCOVID-19- participants
Time frame: 6-months post COVID-19 recovery (Visit 2)
Short-term difference in ventilation defect percent assessed by ventilation SPECT-CT - asthmatic
The short-term difference in lung ventilation between asthmaticCOVID-19+ and asthmaticCOVID-19- participants
Time frame: ≤4-weeks post COVID-19 recovery (Visit 1)
Short-term difference in perfusion defect percent assessed by perfusion SPECT-CT - asthmatic
The short-term difference in lung perfusion between asthmaticCOVID-19+ and asthmaticCOVID-19- participants
Time frame: ≤4-weeks post COVID-19 recovery (Visit 1)
Short-term difference in ventilation/perfusion mismatch assessed by ventilation/perfusion SPECT-CT - asthmatic
The short-term difference in lung ventilation/perfusion mismatch between asthmaticCOVID-19+ and asthmaticCOVID-19- participants
Time frame: ≤4-weeks post COVID-19 recovery (Visit 1)
Long-term difference in ventilation defect percent assessed by ventilation SPECT-CT - asthmatic
The long-term difference in lung ventilation between asthmaticCOVID-19+ and asthmaticCOVID-19- participants
Time frame: 6-months post COVID-19 recovery (Visit 2)
Long-term difference in perfusion defect percent assessed by perfusion SPECT-CT - asthmatic
The long-term difference in lung perfusion between asthmaticCOVID-19+ and asthmaticCOVID-19- participants
Time frame: 6-months post COVID-19 recovery (Visit 2)
Long-term difference in ventilation/perfusion mismatch assessed by ventilation/perfusion SPECT-CT - asthmatic
The long-term difference in lung ventilation/perfusion mismatch between asthmaticCOVID-19+ and asthmaticCOVID-19- participants
Time frame: 6-months post COVID-19 recovery (Visit 2)
Longitudinal change in ventilation defect percent assessed by ventilation SPECT-CT - healthy
Difference in the 6-month change in lung ventilation between healthyCOVID-19+ and healthyCOVID-19- participants
Time frame: 6-months post COVID-19 recovery (Visit 2)
Longitudinal change in perfusion defect percent assessed by perfusion SPECT-CT - healthy
Difference in the 6-month change in lung perfusion between healthyCOVID-19+ and healthyCOVID-19- participants
Time frame: 6-months post COVID-19 recovery (Visit 2)
Longitudinal change in ventilation/perfusion mismatch assessed by ventilation/perfusion SPECT-CT - healthy
Difference in the 6-month change in lung ventilation/perfusion mismatch between healthyCOVID-19+ and healthyCOVID-19- participants
Time frame: 6-months post COVID-19 recovery (Visit 2)
Longitudinal change in ventilation defect percent assessed by ventilation SPECT-CT - asthmatic
Difference in the 6-month change in lung ventilation between asthmaticCOVID-19+ and asthmaticCOVID-19- participants.
Time frame: 6-months post COVID-19 recovery (Visit 2)
Longitudinal change in perfusion defect percent assessed by perfusion SPECT-CT - asthmatic
Difference in the 6-month change in lung perfusion between asthmaticCOVID-19+ and asthmaticCOVID-19- participants.
Time frame: 6-months post COVID-19 recovery (Visit 2)
Longitudinal change in ventilation/perfusion mismatch assessed by ventilation/perfusion SPECT-CT - asthmatic
Difference in the 6-month change in lung ventilation/perfusion mismatch between asthmaticCOVID-19+ and asthmaticCOVID-19- participants.
Time frame: 6-months post COVID-19 recovery (Visit 2)
Correlation of lung ventilation with the St. George's Respiratory Questionnaire (SGRQ) score ≤4-weeks post COVID-19 recovery
In COVID-19+ participants, the correlation of lung ventilation with the St. George's Respiratory Questionnaire (SGRQ) score ≤4-weeks post COVID-19 recovery (Visit 1).
Time frame: ≤4-weeks post COVID-19 recovery (Visit 1)
Correlation of lung ventilation with six-minute walk distance (6MWD) ≤4-weeks post COVID-19 recovery
In COVID-19+ participants, the correlation of lung ventilation with six-minute walk distance (6MWD) ≤4-weeks post COVID-19 recovery (Visit 1).
Time frame: ≤4-weeks post COVID-19 recovery (Visit 1)
Correlation of lung ventilation with the forced expiratory volume in one second (FEV1) ≤4-weeks post COVID-19 recovery
In COVID-19+ participants, the correlation of lung ventilation with the forced expiratory volume in one second (FEV1) ≤4-weeks post COVID-19 recovery (Visit 1).
Time frame: ≤4-weeks post COVID-19 recovery (Visit 1)
Correlation of lung ventilation with the diffusing capacity of the lung for carbon monoxide (DLCO) ≤4-weeks post COVID-19 recovery
In COVID-19+ participants, the correlation of lung ventilation with the diffusing capacity of the lung for carbon monoxide (DLCO) ≤4-weeks post COVID-19 recovery (Visit 1).
Time frame: ≤4-weeks post COVID-19 recovery (Visit 1)
Correlation of lung ventilation with the St. George's Respiratory Questionnaire (SGRQ) score 6-months post COVID-19 recovery
In COVID-19+ participants, the correlation of lung ventilation with the St. George's Respiratory Questionnaire (SGRQ) score 6-months post COVID-19 recovery (Visit 2).
Time frame: 6-months post COVID-19 recovery (Visit 2)
Correlation of lung ventilation with six-minute walk distance (6MWD) 6-months post COVID-19 recovery
In COVID-19+ participants, the correlation of lung ventilation with six-minute walk distance (6MWD) 6-months post COVID-19 recovery (Visit 2).
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Time frame: 6-months post COVID-19 recovery (Visit 2)
Correlation of lung ventilation with the forced expiratory volume in one second (FEV1) 6-months post COVID-19 recovery
In COVID-19+ participants, the correlation of lung ventilation with the forced expiratory volume in one second (FEV1) 6-months post COVID-19 recovery (Visit 2).
Time frame: 6-months post COVID-19 recovery (Visit 2)
Correlation of lung ventilation with the diffusing capacity of the lung for carbon monoxide (DLCO) 6-months post COVID-19 recovery
In COVID-19+ participants, the correlation of lung ventilation with the diffusing capacity of the lung for carbon monoxide (DLCO) 6-months post COVID-19 recovery (Visit 2).
Time frame: 6-months post COVID-19 recovery (Visit 2)