A Study on Brain Activity During Transcranial Direct Current Stimulation in Stroke Patients

N/ACompletedNCT04549753

Samsung Medical Center30 enrolled

Overview

The purpose of this study is to identify the characteristics of neural plasticity seen in stroke patients by measuring the changes in brain activity during stimulation using functional near-infrared spectroscopy (fNIRS) when applying transcranial direct current stimulation (tDCS) for the purpose of enhancing finger function.

Study Type

INTERVENTIONAL

Allocation

NA

Purpose

TREATMENT

Masking

NONE

Enrollment

30

Conditions

Interventions

Transcranial direct current simulationDEVICE

Four sessions of stimulation over C3 (patient with left-sided lesion) or C4 (patient with right-sided lesion) based on 10-20 system

Eligibility

Sex: ALLMin age: 19 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Unilateral stroke patients * Chronic patients over 6 months after onset * Subcortical stroke * Patients with the movement of fingers Exclusion Criteria: * History of psychiatric disease * Significant other neurological diseases except for stroke * Difficult to perform this experiment * Patients with metal implants * History of epilepsy * Pregnancy * Skin defect at the site of electrode attachment

Locations (1)

Samsung Medical Center

Seoul, South Korea

Outcomes

Primary Outcomes

Changes in cortical activity using fNIRS signals during brain stimulation

Cortical activities before and after brain stimulation sessions are compared.

Time frame: Baseline and about 10 days (immediately after brain stimulation sessions)

Secondary Outcomes

Changes in motor evoked potential

Resting motor threshold (rMT) and amplitude of motor evoked potential in first dorsal interosseous muscle are measured. These outcomes are measured by transcranial magnetic stimulation over the motor hotspot. The rMT is defined as the minimum stimulus intensity that produced a minimal motor evoked response at rest. The amplitude means peak to peak of the muscle response.

Time frame: Baseline and about 10 days (immediately after brain stimulation sessions)

9-hole pegboard test

The test is a standardized, quantitative assessment used to measure finger dexterity of a patient.

Time frame: Baseline and about 10 days (immediately after brain stimulation sessions)

Grip & Tip pinch strength test

The test is to measure the maximum isometric strength of hand, forearm, and finger muscles.

Time frame: Baseline and about 10 days (immediately after brain stimulation sessions)

Box & Block test

The test is used to measure the gross manual dexterity of a patient, or of a person using an upper limb prosthetic device.

Time frame: Baseline and about 10 days (immediately after brain stimulation sessions)

Fugl-Meyer Assessment

The score is a stroke-specific, performance-based impairment index. The degree of impairment of upper and lower limbs is measured.

Data from ClinicalTrials.gov

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