GLS4/RTV and TAF Drug-drug Interaction

Inclusion Criteria: * Males or females, of any race, between 18 and 50 years of age, inclusive, at Screening; * Body mass index between 18.0 and 28.0 kg/m2, inclusive, at Screening; * Females of childbearing potential and male subjects will agree to use contraception from screening to the 6 months after the last administration. Exclusion Criteria: * In the 12 months prior to screening, observing clinical significance of the following diseases, including but not limited to, gastrointestinal, kidney, liver, nerve, blood, endocrine, tumor, lung, immune, mental, or cardio-cerebrovascular diseases; * Allergic constitution (multiple drug and food allergies); * A history of alcoholism; * Take any prescription drug, over-the-counter drug, vitamin product or herbal medicine within 14 days of screening; * Any drug that changes the liver enzyme activity, such as barbiturates and Rifampicin, was taken within 30 days before screening; * P-GP, BCRP, OATP1B1, OATP1B3, OAT1, OAT3 or MRP4 inhibitors or inducers, such as azithromycin, pantoprazole or St. John's herb, etc., was taken within 30 days before screening; * Female subjects are lactating or have positive blood pregnancy results during the screening period;