Clinical Efficacy of Combination Therapy Based on High-dose Biapenem in CRKP Infections

Second Affiliated Hospital, School of Medicine, Zhejiang University200 enrolled

Overview

Carbapenem resistance is a high mortality rate of Klebsiella pneumoniae infection. It has been proved that high-dose carbapenem can reduce mortality and has a certain clinical effect. In this study, a high dose of biapenem was compared to determine whether it had a similar effect than meropenem.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

High-dose Biapenem

Interventions

BiapenemDRUG

In the course of CRKP treatment, double dose biapenem was selected.

Eligibility

Sex: ALLMin age: 14 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ICU hospitalized for more than 3 days; * Biapenem used for more than 3 days Exclusion Criteria: * Patients who refuse to be included in the group or pregnant women or under the age of 14 or ICU hospitalized for less than 3 days

Locations (1)

The Second Affiliated Hospital of Zhejiang University Medical College

Hangzhou, Please Select, China

RECRUITING

Outcomes

Primary Outcomes

28-day mortality

Time frame: 2017.01.01-2021.12.31

Secondary Outcomes

Clearance rate of pathogenic microorganisms

Time frame: 2017.01.01-2021.12.31

ICU hospitalization days

Time frame: 2017.01.01-2021.12.31

Central Contacts

Man Huang, Ph D

CONTACT

+8613685753994 deter_leung@zju.edu.cn

Data from ClinicalTrials.gov

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