Recent data suggests that increased temperature improves inotropic function during systole and may improve diastolic function in healthy humans at rest, despite a reduction in left ventricular volume at end diastole. The effect of heat stress has not been reported in patients receiving general anesthesia and the impact of general anesthesia on these findings is not known. Trans-esophageal echocardiography will be used to measure parameters important to both systolic and diastolic function at temperature intervals of 1°C in patients undergoing "Heated Intraoperative Peritoneal Chemotherapy" (HIPEC.) That general anesthesia will not alter the cardiovascular effects of increased temperature that has been reported in healthy, un-anesthetized humans is the hypothesis.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
28
Placement of a transesophageal probe and performance of a diagnostic Transesophageal echocardiography examination.
University of California, San Diego
La Jolla, California, United States
Change in ejection fraction before and after hyperthermia
Time frame: Approximately 6 hours from prior to hyperthermia to during hyperthermia.
Transmitral inflow velocities before and after hyperthermia
Time frame: Approximately 6 hours from prior to hyperthermia to during hyperthermia.
Pulmonary venous inflow velocities before and during hyperthermia
Time frame: Approximately 6 hours from prior to hyperthermia to during hyperthermia.
Mitral annular tissue doppler velocities before and during hyperthermia
Time frame: Approximately 6 hours from prior to hyperthermia to during hyperthermia.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.