This study is intended to determine whether there is a correlation between endometrial compaction and serum progesterone levels on the day of frozen embryo transfers by using transvaginal sonography for the endometrial assessment.
This study is planned to be conducted by prospectively evaluating approximately 200 frozen embryo transfers within 6 months in a single center. Patients planned to be included in the study are started estrodiol 6 mg / day on day2-3 of mensturation. 12 days after the start of estrogen, patients who have endometrial thickness over 7 mm are then started vaginal progesterone supplementation as per routine practice and are eventually proceeded to embryo transfer either on day 4 or 6 of progesterone supplementation. In this study investigators are intended to measure endometrial thickness transvaginally on the day of embryo transfer to accurately determine the presence of endometrial compaction, assess serum progesterone levels, evaluate any possible correlations between endometrial compaction, serum progesterone levels and pregnancy rates.
Study Type
OBSERVATIONAL
Enrollment
200
transvaginal ultrasound performed on day of the start of progesterone supplementation and on the day of frozen embryo transfer; serum progesterone level measurement on day of frozen embryo transfer
Ataşehir Memorial Hospital IVF Department
Istanbul, Turkey (Türkiye)
RECRUITINGOngoing pregnancy rates
Presence of at least one live fetus at the end of the 12th gestational week in patients with endometrial compaction compared to patients without endometrial compaction after frozen embryo transfer
Time frame: 12 weeks after the last menstrual period of the patient
The Correlation of Serum Progesterone Levels With the Degree of Endometrial Compaction on the Day of Frozen Embryo Transfer
endometrium compacted (became thinner) after the administration of progesterone
Time frame: On the day of frozen embryo transfer
Clinical pregnancy rate
Presence of an intrauterine gestational sac with fetal heart beat at 7th week of gestation
Time frame: 6-7 weeks after the last menstrual period of the patient
Implantation rate
Percentage of gestational sacs compared to the number of embryos transferred
Time frame: 5 weeks after the last menstrual period of the patient
Clinical miscarriage rate
pregnancy loss after ultrasonographic detection of an intrauterine gestational sac
Time frame: after 5th gestational week
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