Regional Hypothermia in Combination With Endovascular Thrombectomy in Acute Ischemic Stroke

Inclusion Criteria: * Age ≥18 and ≤80 * Clinical signs consistent with the diagnosis of an acute ischemic stroke * Baseline NIHSS score obtained prior to randomization ≥8 * Intracranial arterial occlusion of the distal intracranial carotid artery or * Middle (M1/M2), demonstrated with CTA, MRA, DSA * The possibility to start treatment (artery puncture) within 6 hours from onset * Regional hypothermia is expected to start within 15 minutes after recanalization * Informed consent given Exclusion Criteria: * mTICI\<2b after endovascular treatment * No significant pre-stroke disability (mRS ≤1) * Previous NYHA grade \> 1 * Known hemorrhagic diathesis, coagulation factor deficiency, or oral anticoagulant therapy with INR \> 3.0 * Baseline platelet count \< 50000/µL * Baseline blood glucose of \< 50mg/dL or \>400mg/dl * Severe, sustained hypertension (SBP \> 220 mm Hg or DBP \> 110 mm Hg). NOTE: If the blood pressure can be successfully reduced and maintained at the acceptable level using local treatment guidelines recommended medication (including iv antihypertensive drips), the patient can be enrolled. * Seizures at stroke onset which would preclude obtaining a baseline NIHSS * Subjects who have received iv t-PA treatment beyond 4,5 hours from the beginning of the symptoms * Renal insufficiency with creatinine ≥ 3 mg/dl * Woman of childbearing potential who is known to be pregnant or lactating * Subject participating in a study involving an investigational drug or device that would impact this study * Cerebral vasculitis * Patients with a pre-existing neurological or psychiatric disease that would confound the neurological or functional evaluations * Unlikely to be available for 3 months follow-up (e.g. no fixed home address, visitor from overseas). * CT or MR evidence of hemorrhage (the presence of microbleeds on MRI is allowed) * ASPECT\<6 * Subjects with occlusions in multiple vascular territories (anterior circulation and posterior circulation) * Evidence of intracranial tumor (except small meningioma)