A Study to Compare the Effectiveness of Different High-intensity Interval Training Programs in Cardiac Rehabilitation

N/AActive Not RecruitingNCT04555512

Mayo Clinic30 enrolled

Overview

The purpose of the study is to examine the effect of two different high intensity interval training (HIIT) prescription approaches on improving fitness, heart function, and the ability of the body's muscles to receive oxygen.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Cardiac Rehabilitation

Interventions

Progressive High Intensity Interval Training (PRO-HIIT)OTHER

Individual exercise training sessions, involving two weeks of moderate intensity continuous exercise and 10 weeks of interval exercise training. This protocol involves progression of training of 3 stages: 1) six high-intensity intervals (at an RPE of 15-18) of 1-min separated by five low-intensity intervals of 2-min; 2) three high-intensity intervals of 2-min separated by two low-intensity intervals of 4-min, and a further 2-min of low intensity following the last interval before cool-down; and 3) three high-intensity intervals of 3-min separated by two low-intensity intervals of 3-min, and a further 1-min of low intensity following last interval before cool-down.

Constant High Intensity Interval Training (CON-HIIT)OTHER

Individual exercise training sessions, involving two weeks of moderate intensity continuous exercise and 10 weeks of interval exercise training. This protocol involves a constant protocol of training, including six high-intensity intervals (at an RPE of 15-18) of 1-min separated by five low-intensity intervals of 2-min.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult 18 years and older. * English speaking. * Able to provide consent. * Has a qualifying indication for center-based cardiac rehabilitation that is non-surgical (i.e., Acute coronary syndrome, myocardial infarction, percutaneous coronary intervention, and stable angina). Exclusion Criteria: * Participants referred to cardiac rehabilitation following coronary artery bypass surgery, heart valve repair/replacement, heart transplant, or those with ventricular assist devices. * Patients who are unable to engage in a regularly structured exercise training program as part of a clinically indicated center-based outpatient cardiac rehabilitation program are not eligible. * Patients unable/unwilling to provide informed consent will not be enrolled. * Patients identified as having a contraindication to high intensity exercise.

Locations (1)

Mayo Clinic in Rochester

Rochester, Minnesota, United States

Outcomes

Primary Outcomes

Change in cardiorepiratory fitness

Measure as peak oxygen consumption (VO2 peak)

Time frame: Pre and post study completion, approximately 12 weeks

Secondary Outcomes

Change in oxygen uptake response time

Measured as exponential time-constant of pulmonary oxygen uptake at exercise onset

Time frame: Weekly, over 12 weeks

Change in locomotor muscle oxygenation

Measured as tissue oxygen saturation by near-infrared spectroscopy (NIRS)