Using Multi-tracer to early diagnosis of therapy-associated cardiotoxicity using multimodality PET/MRI.
In this study investigators evaluated cardiac uptake by different molecular probe such as FDG, FAPI-04 using multimodality PET/MRI. Previous studies have shown that increased cardiac uptake of FDG on PET may be an indicator of myocardial injury after chemotherapy. Cardiac magnetic resonance (CMR) allows for multiparametric evaluation of cardiac morphology, ventricular function, myocardial perfusion, and viability. The combination of PET with MR (PET/MR) is therefore an alternative attractive pairing for diagnostic imaging. The aim of this study is to find noninvasive and effective method for early diagnosis of cardiotoxicity after chemotherapy or immunotherapy
Study Type
OBSERVATIONAL
Enrollment
120
Peking University Cancer Hospital
Beijing, Beijing Municipality, China
RECRUITINGSUVR
the ratio of the standardized uptake value(SUVR) of multi-tracer for the heart within each time window to that of the normal tissue such as hepatic blood pool、blood pool and gluteus.
Time frame: 150 days
Change Of Mapping Value and LVEF From Baseline
The change of mapping value and left ventricular ejection fraction between the value before treatment and the value after treatment was calculated based on cardiac magnetic resonance
Time frame: 150 days
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