TEWL Biomarker Study for Diabetic Foot Ulcer Recurrence

Inclusion Criteria: In order to be eligible to participate in this study, an individual must meet all of the following criteria at Visit 1: 1. Age \> 18 years. 2. Willing and able to comply with protocol instructions. 3. Clinically diagnosed DFU is closed. 4. Clinically diagnosed with diabetes or meeting the American Diabetes Association (ADA) criteria. 5. Provides written informed consent. At Visit 2, confirmation of complete wound healing, the following additional inclusion criterion must be met: 6. Confirmation that the target DFU that was assessed as healed at Visit 1 remains healed two weeks later (at Visit 2). Exclusion Criteria: An individual who meets any of the following criteria will be excluded from participation in this study: 1. DFU wounds closed more than 2 weeks before Visit 1, or to be closed by flap or graft coverage 2. Closed DFU site whose size or location would not allow five separate TEWL measurements 3. Prisoners