The purpose of this research is to compare a single shot long acting local anesthetic to catheter infusion of local anesthetic in patients undergoing video assisted thoracoscopic (VAT) surgery.
The purpose of this research is to compare Single Shot Liposomal Bupivacaine (EXPAREL®)/Bupivacaine (a long acting local anesthetic) to Ropivacaine (0.5% bolus followed by 0.2% infusion of local anesthetic using a catheter) in patients undergoing video assisted thoracoscopic (VAT) surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
45
Single shot for erector spinae block
Continuous catheter infusion for erector spinae plane block
Robert Packer Hospital
Sayre, Pennsylvania, United States
Numeric Rated Pain Scale at Rest 0-4 Hours Post-operative
Patient reported pain scale (0-10) with zero (0) meaning "no pain" and ten (10) meaning "the worst pain imaginable
Time frame: 0-4 hours post operative
Numeric Rated Pain Scale at Rest 4-8 Hours Post-operative
Patient reported pain scale (0-10) with zero (0) meaning "no pain" and ten (10) meaning "the worst pain imaginable
Time frame: 4-8 hours post operative
Numeric Rated Pain Scale at Rest 8-12 Hours Post-operative
Patient reported pain scale (0-10) with zero (0) meaning "no pain" and ten (10) meaning "the worst pain imaginable
Time frame: 8-12 hours post operative
Numeric Rated Pain Scale at Rest 12-24 Hours Post-operative
Patient reported pain scale (0-10) with zero (0) meaning "no pain" and ten (10) meaning "the worst pain imaginable
Time frame: 12-24 hours post operative
Numeric Rated Pain Scale at Rest 24-48 Hours Post-operative
Patient reported pain scale (0-10) with zero (0) meaning "no pain" and ten (10) meaning "the worst pain imaginable
Time frame: 2 days post operative
Numeric Rated Pain Scale 48-72 Hours Post-operative
Patient reported pain scale (0-10) with zero (0) meaning "no pain" and ten (10) meaning "the worst pain imaginable
Time frame: 3 days post-operative
Numeric Rated Pain Scale With Cough 0-4 Hours Post-operative
Patient reported pain with cough on a scale (0-10) with zero (0) meaning "no pain" and ten (10) meaning "the worst pain imaginable
Time frame: 0-4 hours post-operative
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Numeric Rated Pain Scale With Cough 4-8 Hours Post-operative
Patient reported pain with cough on a scale (0-10) with zero (0) meaning "no pain" and ten (10) meaning "the worst pain imaginable
Time frame: 4-8 hours post-operative
Numeric Rated Pain Scale With Cough 8-12 Hours Post-operative
Patient reported pain with cough on a scale (0-10) with zero (0) meaning "no pain" and ten (10) meaning "the worst pain imaginable
Time frame: 8-12 hours post-operative
Numeric Rated Pain Scale With Cough 12-24 Hours Post-operative
Patient reported pain with cough on a scale (0-10) with zero (0) meaning "no pain" and ten (10) meaning "the worst pain imaginable
Time frame: 12-24 hours post-operative
Numeric Rated Pain Scale With Cough 24-48 Hours Post-operative
Patient reported pain with cough on a scale (0-10) with zero (0) meaning "no pain" and ten (10) meaning "the worst pain imaginable
Time frame: 24-48 hours post-operative
Numeric Rated Pain Scale With Cough 48-72 Hours Post-operative
Patient reported pain with cough on a scale (0-10) with zero (0) meaning "no pain" and ten (10) meaning "the worst pain imaginable
Time frame: 48-72 hours post-operative
Opioid Consumption in Morphine Equivalent Dose 0-4 Hours Post-operative
Post-operative opioid consumption in morphine equivalent dose (MED) to determine total opioid medications given in the time period. MED is a standard conversion factor developed by the United States Centers for Disease Control and Prevention (CDC). The MED equates the many different opioids into a standard value that is based on morphine and its potency.
Time frame: 0-4 hours post-operative
Opioid Consumption in Morphine Equivalent Dose 4-8 Hours Post-operative
Post-operative opioid consumption in morphine equivalent dose (MED) to determine total opioid medications given in the time period. MED is a standard conversion factor developed by the United States Centers for Disease Control and Prevention (CDC). The MED equates the many different opioids into a standard value that is based on morphine and its potency.
Time frame: 4-8 hours post-operative
Opioid Consumption in Morphine Equivalent Dose 8-16 Hours Post-operative
Post-operative opioid consumption in morphine equivalent dose (MED) to determine total opioid medications given in the time period. MED is a standard conversion factor developed by the United States Centers for Disease Control and Prevention (CDC). The MED equates the many different opioids into a standard value that is based on morphine and its potency.
Time frame: 8-16 hours post-operative
Opioid Consumption in Morphine Equivalent Dose 16-24 Hours Post-operative
Post-operative opioid consumption in morphine equivalent dose (MED to determine total opioid medications given in the time period. MED is a standard conversion factor developed by the United States Centers for Disease Control and Prevention (CDC). The MED equates the many different opioids into a standard value that is based on morphine and its potency.
Time frame: 16-24 hours post-operative
Opioid Consumption in Morphine Equivalent Dose 24-48 Hours Post-operative
Post-operative opioid consumption in morphine equivalent dose (MED) to determine total opioid medications given in the time period. MED is a standard conversion factor developed by the United States Centers for Disease Control and Prevention (CDC). The MED equates the many different opioids into a standard value that is based on morphine and its potency.
Time frame: 24-48 hours post-operative
Opioid Consumption in Morphine Equivalent Dose 48-72 Hours Post-operative
Post-operative opioid consumption in morphine equivalent dose (MED) to determine total opioid medications given in the time period. MED is a standard conversion factor developed by the United States Centers for Disease Control and Prevention (CDC). The MED equates the many different opioids into a standard value that is based on morphine and its potency.
Time frame: 48-72 hours post-operative
Total Intraoperative Opioid Consumption in Morphine Equivalent Dose
Total opioids administered in morphine equivalent dose (MED) in the operating room during the surgery. MED is a standard conversion factor developed by the United States Centers for Disease Control and Prevention (CDC). The MED equates the many different opioids into a standard value that is based on morphine and its potency.
Time frame: From start of surgery to end of surgery, an average of 2-3 hours
Acetaminophen Consumption in Milligrams 0-4 Hours Post-operative
Acetaminophen is a pain medication that is not an opioid. The acetaminophen use in milligrams will be compared in each group at different time points.
Time frame: 0-4 hours post-operative
Acetaminophen Consumption in Milligrams 4-8 Hours Post-operative
Acetaminophen is a pain medication that is not an opioid. The acetaminophen use in milligrams will be compared in each group at different time points.
Time frame: 4-8 hours post-operative
Acetaminophen Consumption in Milligrams 8-16 Hours Post-operative
Acetaminophen is a pain medication that is not an opioid. The acetaminophen use in milligrams will be compared in each group at different time points.
Time frame: 8-16 hours post-operative
Acetaminophen Consumption in Milligrams 16-24 Hours Post-operative
Acetaminophen is a pain medication that is not an opioid. The acetaminophen use in milligrams will be compared in each group at different time points.
Time frame: 16-24 hours post-operative
Acetaminophen Consumption in Milligrams 24-48 Hours Post-operative
Acetaminophen is a pain medication that is not an opioid. The acetaminophen use in milligrams will be compared in each group at different time points.
Time frame: 24-48 hours post-operative
Acetaminophen Consumption in Milligrams 48-72 Hours Post-operative
Acetaminophen is a pain medication that is not an opioid. The acetaminophen use in milligrams will be compared in each group at different time points.
Time frame: 48-72 hours post-operative
Gabapentin Consumption in Milligrams 0-4 Hours Post-operative
Gabapentin is a pain medication that is not an opioid. The gabapentin use in milligrams will be compared in each group at different time points.
Time frame: 0-4 hours post-operative
Gabapentin Consumption in Milligrams 4-8 Hours Post-operative
Gabapentin is a pain medication that is not an opioid. The gabapentin use in milligrams will be compared in each group at different time points.
Time frame: 4-8 hours post-operative
Gabapentin Consumption in Milligrams 8-16 Hours Post-operative
Gabapentin is a pain medication that is not an opioid. The gabapentin use in milligrams will be compared in each group at different time points.
Time frame: 8-16 hours post-operative
Gabapentin Consumption in Milligrams 16-24 Hours Post-operative
Gabapentin is a pain medication that is not an opioid. The gabapentin use in milligrams will be compared in each group at different time points.
Time frame: 16-24 hours post-operative
Gabapentin Consumption in Milligrams 24-48 Hours Post-operative
Gabapentin is a pain medication that is not an opioid. The gabapentin use in milligrams will be compared in each group at different time points.
Time frame: 24-48 hours post-operative
Gabapentin Consumption in Milligrams 48-72 Hours Post-operative
Gabapentin is a pain medication that is not an opioid. The gabapentin use in milligrams will be compared in each group at different time points.
Time frame: 48-72 hours post-operative
Ketorolac Consumption in Milligrams 0-4 Hours Post-operative
The ketorolac use in milligrams will be compared in each group at different time points.
Time frame: 0-4 hours post-operative
Ketorolac Consumption in Milligrams 4-8 Hours Post-operative
The ketorolac use in milligrams will be compared in each group at different time points.
Time frame: 4-8 hours post-operative
Ketorolac Consumption in Milligrams 8-16 Hours Post-operative
The ketorolac use in milligrams will be compared in each group at different time points.
Time frame: 8-16 hours post-operative
Ketorolac Consumption in Milligrams 16-24 Hours Post-operative
The ketorolac use in milligrams will be compared in each group at different time points.
Time frame: 16-24 hours post-operative
Ketorolac Consumption in Milligrams 24-48 Hours Post-operative
The ketorolac use in milligrams will be compared in each group at different time points.
Time frame: 24-48 hours post-operative.
Ketorolac Consumption in Milligrams 48-72 Hours Post-operative
Ketorolac is a pain medication that is not an opioid. The ketorolac use in milligrams will be compared in each group at different time points.
Time frame: 48-72 hours post-operative
Postoperative Quality of Recovery Score (QOR-15) 12-24 Hours Post-operative
A survey on patient reported outcomes which consists of 15 questions related to five domains of patient reported health status (pain, physical comfort, physical independence, psychological support and emotional state). The score is reported on a scale from 0 to 150 with higher scores meaning a better outcome.
Time frame: 12-24 hours post-operative
Postoperative Quality of Recovery Score (QOR-15) 24 to 48 Hours Post-operative
A survey on patient reported outcomes which consists of 15 questions related to five domains of patient reported health status (pain, physical comfort, physical independence, psychological support and emotional state). The score is reported on a scale from 0 to 150 with higher scores meaning a better outcome.
Time frame: 24-48 hours post-operative
Postoperative Quality of Recovery Score (QOR-15) 48 to 72 Hours Post-operative
A survey on patient reported outcomes which consists of 15 questions related to five domains of patient reported health status (pain, physical comfort, physical independence, psychological support and emotional state). The score is reported on a scale from 0 to 150 with higher scores meaning a better outcome.
Time frame: 48-72 hours post-operative
Post-operative Incentive Spirometry Changes From Preoperative Baseline at 0-4 Hours Post-operative
Incentive spirometry measures how much air you can inhale, which can help indicate how well your lungs are working after surgery. Incentive spirometry measures the volume (or amount) of air you inhale measured in cubic centimeters (cc). Higher numbers indicate that you're inhaling more air. This measure will be the change in incentive spirometry from baseline (baseline incentive spirometry - incentive spirometry 0 to 4 hours post-operative). A negative number reflects reduced volume of air.
Time frame: 0-4 hours post-operative
Post-operative Incentive Spirometry Changes From Preoperative Baseline at 4-8 Hours Post-operative
Incentive spirometry measures how much air you can inhale, which can help indicate how well your lungs are working after surgery. Incentive spirometry measures the volume (or amount) of air you inhale measured in cubic centimeters (cc). Higher numbers indicate that you're inhaling more air. This measure will be the change in incentive spirometry from baseline (baseline incentive spirometry - incentive spirometry 4 to 8 hours post-operative). A negative number reflects reduced volume of air.
Time frame: 4-8 hours post-operative
Post-operative Incentive Spirometry Changes From Preoperative Baseline at 8-12 Hours Post-operative
Incentive spirometry measures how much air you can inhale, which can help indicate how well your lungs are working after surgery. Incentive spirometry measures the volume (or amount) of air you inhale measured in cubic centimeters (cc). Higher numbers indicate that you're inhaling more air. This measure will be the change in incentive spirometry from baseline (baseline incentive spirometry - incentive spirometry 8 to 12 hours post-operative). A negative number reflects reduced volume of air.
Time frame: 8-12 hours post-operative
Post-operative Incentive Spirometry Changes From Preoperative Baseline at 12-24 Hours Post-operative
Incentive spirometry measures how much air you can inhale, which can help indicate how well your lungs are working after surgery. Incentive spirometry measures the volume (or amount) of air you inhale measured in cubic centimeters (cc). Higher numbers indicate that you're inhaling more air. This measure will be the change in incentive spirometry from baseline (baseline incentive spirometry - incentive spirometry 12 to 24 hours post-operative). A negative number reflects reduced volume of air.
Time frame: 12-24 hours post-operative
Post-operative Incentive Spirometry Changes From Preoperative Baseline at 24-48 Hours Post-operative
Incentive spirometry measures how much air you can inhale, which can help indicate how well your lungs are working after surgery. Incentive spirometry measures the volume (or amount) of air you inhale measured in cubic centimeters (cc). Higher numbers indicate that you're inhaling more air. This measure will be the change in incentive spirometry from baseline (baseline incentive spirometry - incentive spirometry 24 to 48 hours post-operative). A negative number reflects reduced volume of air.
Time frame: 24-48 hours post-operative
Post-operative Incentive Spirometry Changes From Preoperative Baseline at 48-72 Hours Post-operative
Incentive spirometry measures how much air you can inhale, which can help indicate how well your lungs are working after surgery. Incentive spirometry measures the volume (or amount) of air you inhale measured in cubic centimeters (cc). Higher numbers indicate that you're inhaling more air. This measure will be the change in incentive spirometry from baseline (baseline incentive spirometry - incentive spirometry 48 to 72 hours post-operative). A negative number reflects reduced volume of air.
Time frame: 48-72 hours post-operative
Length of Hospital Stay
Number of hours from admission to discharge
Time frame: From date of admission until date of discharge, an average of 72 hours