Effect of Magnesium Sulphate Added to Mepivacaine Hydrochloride on Inferior Alveolar Nerve Block Success in Patients With Symptomatic Irreversible Pulpitis in Mandibular Molars: A Randomized Clinical Trial.

N/AUnknownNCT04561921

Cairo University56 enrolled

Overview

the study is conducted to assess the effect of adding magnesium sulphate to mepivacaine HCl compared to mepivacaine HCl alone on the success of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis in mandibular molars

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Success of Inferior Alveolar Nerve Block

Interventions

Magnesium sulfateDRUG

patients will be given an IANB injection by adding 0.18 mL of 10% magnesium sulphate to 1.8 ml of 2% mepivacaine HCL with Levonordefrin HCl 1:20000/ 1.8 ml , after withdrawal of 0.18ml from the local anesthetic carpule by using a 100 IU insulin syringe

Mepivacaine-Levonordefrin HydrochlorideDRUG

patients will be given an IANB injection by adding 0.18 mL of sterile distilled water to 1.8 ml of 2% mepivacaine HCL with Levonordefrin HCl 1:20000/ 1.8 ml , after withdrawal of 0.18ml from the local anesthetic carpule by using a 100 IU insulin syringe

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age between 18-55 years old. 2. Systemically healthy patient (ASA I or II). 3. Mandibular molar teeth with: * Preoperative sharp pain. * No widening in the periodontal ligament (PDL). * Vital response of pulp tissue to cold pulp tester (ethyl chloride spray)1. * Fully formed roots. 4. Positive patient's acceptance for participation in the study. Exclusion Criteria: 1. Patients who had used any type of analgesic medication during the preceding 12 hours before the treatment. 2. Pregnant or nursing females. 3. Patients having significant systemic disorder (ASA III or IV). 4. Drug abusers and subjects who were on antidepressant medication. 5. Re-treatment cases. 6. Patients with a contraindication for the use of magnesium sulphate or those known to be allergic to any of the study medications.

Outcomes

Primary Outcomes

success of inferior alveolar nerve block measured using a numerical rating scale (NRS)

Intensity of pain 15 minutes after injection during access cavity and initial file placement is recorded by the patient using a numerical rating scale(where 0= no pain ,1-3 =mild pain ,4-6= moderate pain and 7-9= severe pain )

Time frame: 15 minutes after injection

Central Contacts

alaa Ib mekhimar, B.D.S

CONTACT

01096404006 alaa.ibrahim.ghazy@gmail.com

Data from ClinicalTrials.gov

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