Stratified vs Routine Prophylaxis in Living Kidney Transplantation From HBsAg+ Donors to HBsAg- Recipients

Inclusion Criteria: 1. patients diagnosed with end-stage renal diseases and suitable for living kidney transplantation; 2. HBsAg+ donor was the only donor; 3. age and sex of donors and recipients were unrestricted; 4. ABO compatible or incompatible between the donor and recipient; 5. The living donor voluntarily donates one of their kidneys to the recipient free of charge; 6. The donor and recipient can understand the purpose and risk of living KT and sign informed consent; 7. Ethics committee approved. Exclusion Criteria: 1. preoperative abnormal liver dysfunction in the donor or recipient (ALT \> 60IU/L for females, and \>75 IU/L for males; or total bilirubin \> 34 umol/L); or preoperative ultrasonography in the donor or recipient reported hepatic cirrhosis; 2. positive complement-dependent cytotoxicity cross-match test; 3. combined HCV or HIV infection in the donor or recipient; 4. diagnosed with malignancy or had a history of malignancy in the past 5 years; 5. non-kidney transplantation history.