Lung Ultrasound in Procalcitonin- Guided Antibiotic Discontinuation in Ventilator Associated Pneumonia

Ain Shams University62 enrolled

Overview

Ventilator Associated pneumonia (VAP) is associated with longer ICU length of stay, prolonged mechanical ventilation, and increased use of antimicrobials, health-care cost and mortality . Acute respiratory infections (ARIs) comprise a large and heterogeneous group of infections, including bacterial infections, viral infections, and infections of other etiologies. Early initiation of adequate antibiotic therapy is the cornerstone in the treatment. However, overuse of antibiotics and prolonged duration of antibiotic therapy in patients with bacterial ARIs in the hospital and intensive care setting is associated with increased resistance for common bacteria, high costs, and adverse drug reactions.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Ventilator Associated Pneumonia

Interventions

Lung UltrasoundDIAGNOSTIC_TEST

We will evaluate the role of lung ultrasound on the duration of antibiotics, we hypothesize that ultrasound imaging may have a role, will be correlated with, procalcitonin (PCT). The created database will help in establishing conclusion and recommendations that will help to improve the antibiotics duration and decrease the resistance.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years old or greater * Ventilator associated pneumonia (VAP) with positive sputum culture. Exclusion Criteria: * pregnancy, * use of immunosuppressive agents except for steroids, * neutropenia (white blood cell count ≤1000/mL) * patients whose primary diagnosis was community acquired pneumonia and other source of infection.

Lung Ultrasound in Procalcitonin- Guided Antibiotic Discontinuation in Ventilator Associated Pneumonia

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes