BAFF/IL-17 Bispecific Antibody Treatment in Subjects With Primary Sjogren's Syndrome

Inclusion Criteria: * Men and women 18-85 years of age * Confirmed diagnosis of primary Sjogren's syndrome by the 2016 ACR-EULAR classification criteria for primary Sjogren's syndrome * All women (regardless of childbearing potential) must test negative for pregnancy at the time of screening * Women must also agree to use a reliable method of birth control from screening until 12 weeks following last dose of study drug unless they are not of child bearing potential * Have stimulated whole salivary flow rate of greater than or equal to 0.10 ml/minute * Have a salivary gland total ultrasound score (TUS) of less than or equal to 9 (on a 0-11 point scale) Exclusion Criteria: * Currently enrolled in a clinical trial involving an investigational product or off-label use of a drug * Concurrently enrolled in any other type of medical research judged not to be scientifically or medically compatible with this study * Have received any nonbiologic investigational product within 30 days or 5 half-lives (whichever is longer) of their baseline (Day 1) visit * Have received any biologic investigational product within 3 months or 5 half-lives (whichever is longer) of their baseline visit, or any leukocyte depleting agent within 12 months of baseline * Have disease-modifying antirheumatic drug (DMARD) or immunosuppressive use as follows: * ANY treatment with a janus kinase (JAK) inhibitor (including but not limited to tofacitinib, baricitinib, upadacitinib, or filgotinib) within 28 days prior to baseline or planned treatment with a JAK inhibitor during the study * UNSTABLE PRESCRIBED DOSE of other synthetic DMARDs (eg, hydroxychloroquine, methotrexate, leflunomide, or sulfasalazine) within 28 days prior to baseline or if the dose of drug is planned to be increased during the study (stable prescriptions are allowed) * ANY treatment with cytotoxic or immunosuppressive drugs including but not limited to cyclophosphamide, mycophenolic acid, azathioprine, cyclosporine, sirolimus, or tacrolimus within 28 days prior to screening or planned treatment during the study * Have had treatment with biologic DMARDs as follows: Etanercept, adalimumab, or anakinra \<4 weeks before baseline or planned treatment during the study * Have had treatment with biologic DMARDs as follows: Infliximab, certolizumab pegol, golimumab, abatacept, or tocilizumab \<8 weeks before baseline or planned treatment during the study * Are persons who have previously completed or withdrawn from this study