Physiopathology and Sequelae of COVID-19 Infection

N/AActive Not RecruitingNCT04563676

Centre Hospitalier Universitaire, Amiens400 enrolled

Overview

The data obtained from Covid-19 infections seem to suggest that the immunogenesis of Covid-19 could in some cases be the result of immune dysregulation. On the other hand, endocrine damage is possible at the tile of Covid-19 infection (mainly thyroid,adrenal, and hypothalamus). These disorders are autoimmune or linked to degeneration. The main objective is to assess the thyroid function (thyrotropic axis) as well as the corticotropic adrenal function of patients who have had Copvid-19 pneumonia. The secondary objectives is to describe the pathophysiological mechanisms of pulmonary and vasculothrombotic involvement of Covid-19

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

400

Conditions

Covid19 TSH Cortisol

Interventions

covid19 infected patient will have a blood test in order to make an autoimmune assessment (antinuclear antibodies, soluble nuclear anti-antigen, ANCA, antiphospholipid antibodies, FT3, FT4 , TSH, antithyroid antibodies, ACTH cortisol, and creation of a serotheque).

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patient having a covid19 infection hospitalized at the Amiens Picardie University Hospital * Patient who is seen in Pneumology consultation for a respiratory assessment at 3 months of his hospitalization (between M2 and M4) to evaluate presence of respiratory sequelae * Patient who agreed to participate in the protocol * Patient affiliated to a Social Security Exclusion Criteria: * patient under guardianship or curators * patient refusing to participate

Outcomes

Primary Outcomes

8-hour cortisol level in patients with Covid19 pneumonia

8-hour cortisol level in patients with Covid19 pneumonia will be determined the day of consultation for respiratory sequelae.

Time frame: day 0

TSH level in patients with Covid19 pneumonia

TSH level in patients with Covid19 pneumonia will be determined the day of consultation for respiratory sequelae.