Patients with chronic kidney disease (CKD) have a higher risk of fractures than those without. The purpose of this study is to develop a non-invasive Magnetic resonance imaging (MRI) method that can improve fracture risk prediction and provide early diagnosis for bone abnormalities in patients with CKD.
Chronic Kidney Disease-Mineral and Bone Disorder (MBD） is a common complication of chronic kidney disease (CKD), which may lead to defective mineralization, altered bone morphology, and/or bone turnover. Animal research found that bone changes occur even in the early stage of CKD , and with CKD progression, the patient may show symptoms such as bone pain, joint pain, bone deformation, and even spontaneous fractures. Despite significant advances in understanding bone disease in CKD, most clinical and biochemical targets used in clinical practice remain controversial, resulting in an undermanagement of bone fragility.Our ability to diagnose CKD-MBD and to initiate strategies that could prevent fractures remains limited by the lack of accurate and noninvasive diagnostic tools. The purpose of this study is to develop a non-invasive method that can improve fracture risk prediction and provide early diagnosis for bone abnormalities in patients with CKD.
Study Type
OBSERVATIONAL
Enrollment
200
Bone mineral density was examined in all cases and controls
Tongji Hospital
Wuhan, Hubei, China
RECRUITINGMagnetic resonance examination for general diagnosis：routine imaging sequences
All MRI imaging was performed on a clinical 3.0 T General Electric(GE) MR scanner on the lumbar spine and lower legs of both experimental group and control group.
Time frame: 12 months
Magnetic resonance examination to measure tissue diffusion and perfusion：DWI-related sequence
All MRI imaging was performed on a clinical 3.0 T General Electric(GE) MR scanner on the lumbar spine and lower legs of both experimental group and control group.And the full abbreviation of the above sequence:Diffusion Weighted Imaging(DWI)-related sequence
Time frame: 12 months
Magnetic resonance examination to measure material changes in tissue：CEST
All MRI imaging was performed on a clinical 3.0 T General Electric(GE) MR scanner on the lumbar spine and lower legs of both experimental group and control group.And the full abbreviation of the above sequence: chemical exchange saturation transfer(CEST)
Time frame: 12 months
Magnetic resonance examination to measure the fat content of tissues：IDEAL- IQ
All MRI imaging was performed on a clinical 3.0 T General Electric(GE) MR scanner on the lumbar spine and lower legs of both experimental group and control group.And the full abbreviation of the above sequence：iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) - intelligent quantification (IQ)
Time frame: 12 months
Magnetic resonance examination with ultrashort echo time to imaging musculoskeletal ：UTE
All MRI imaging was performed on a clinical 3.0 T General Electric(GE) MR scanner on the lumbar spine and lower legs of both experimental group and control group. And the full abbreviation of the above sequence: ultrashort echo time (UTE)
Time frame: 12 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Magnetic resonance examination for bone morphological observation: ZTE
All MRI imaging was performed on a clinical 3.0 T General Electric(GE) MR scanner on the lower legs of both experimental group and control group.And the full abbreviation of the above sequence: Zero-Echo Time(ZTE)
Time frame: 12 months
Magnetic resonance examination to measure changes in the relaxation rate of muscles and blood vessels: SWI
All MRI imaging was performed on a clinical 3.0 T General Electric(GE) MR scanner on the lower legs of both experimental group and control group. And the full abbreviation of the above sequence: Susceptibility-weighted Imaging(SWI)
Time frame: 12 months
Bone mineral density（BMD）measured by DXA
The dual energy x-ray absorptiometry (DXA) was performed on the lumbar spine of both experimental group and control group.
Time frame: 12 months
Blood biochemistry ：Routine blood was used to detect anemia
Routine blood samples were collected from individuals in the experimental group
Time frame: 12 months
Blood biochemistry ：renal function was used for staging CKD
Renal function samples were collected from individuals in the experimental group and control group
Time frame: 12 months
Blood biochemistry ：Serum electrolyte was used to detect electrolyte changes
Serum electrolyte samples were collected from individuals in the experimental group
Time frame: 12 months
Blood biochemistry ：the ALP、PTH、25-OH VitD、osteocalcin、T-P1NP and β-CTX were used to detect bone metabolism
The above serum samples were collected from individuals in the experimental group
Time frame: 12 months
Blood biochemistry ： blood glucose was used to determine the presence or absence of diabetes
Blood glucose samples were collected from individuals in the experimental group
Time frame: 12 months
Blood biochemistry ：CK(Creatine kinase) was used to detect muscle lesions
CK samples were collected from individuals in the experimental group
Time frame: 12 months
The urine routine was examined to determine whether individuals in the control group and the experimental group had hematuria and proteinuria
The Routine urine samples were collected from individuals in the experimental group and control group
Time frame: 12 months