Influence of Periodontitis and Coronary Heart Disease on Galectin-3

University of Messina155 enrolled

Overview

The aim of this study was to analyze the association between serum and salivary Galectin-3 levels in patients with periodontitis. Furthermore, the objective was to determine if the periodontitis influenced serum and salivary Galectin-3 levels

Healthy controls (n=38), patients with CHD (n=39), periodontitis (n=40), and a combination of periodontitis + CHD (n=38) were enrolled in the present study. The analyzed sample undergo a demographical, clinical and periodontal evaluation and serological analyses including Endothelin-1 (ET-1) and for serum and salivary Galectin-3 levels.

Study Type

OBSERVATIONAL

Enrollment

155

Conditions

Periodontal Diseases

Interventions

Observation of serum and salivary Galectin-3 levelsOTHER

Observation of serum and salivary Galectin-3 levels and correlation with periodontal indices

Eligibility

Sex: ALLMin age: 30 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Presence of at least 16 teeth * CP with a minimum of 40% of sites with a clinical attachment level (CAL) ≥2mm and probing depth (PD) ≥4mm; * Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs * Presence of ≥40% sites with bleeding on probing (BOP) Exclusion Criteria: * Intake of contraceptives * Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study * Status of pregnancy or lactation * Previous history of excessive drinking * Allergy to local anaesthetic * Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.

Locations (1)

University of Messina

Messina, Italy

Outcomes

Primary Outcomes

Changes of Clinical Attachment Level (mm)

Measurment of changes in Clinical Attachment Level

Time frame: 1-year

Data from ClinicalTrials.gov

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