Pharmacokinetics of Yimitasvir Phosphate Capsule in Subjects With Normal Renal Function and ESRD

Inclusion Criteria: 1. male or female, age 18 to 70 years of age, inclusive; 2. must have a calculated body mass index (BMI) from 18 to 28 kg/m2 at study screening; 3. Glomerular filtration rate must be \< 15 mL/min /1.73 m2 for End-stage renal disease without hemodialysis group, and ≥ 90 mL/min for Normal Renal Function group(using MDRD method); 4. matched for age (±5 years) ,gender and BMI(±15%) with a subject in the End-stage renal disease without hemodialysis group; Exclusion Criteria: 1. allergies constitution ( multiple drug and food allergies); 2. Use of \>5 cigarettes per day during the past 3 months; 3. A positive test results for HbsAg, Hepatitis C antibody, HIV-1 antibody, or Treponema pallidum antibody； 4. History of alcohol abuse； 5. Donation or loss of blood over 400 mL within 3 months prior to the first dose of study drug； 6. Subjects deemed unsuitable by the investigator for any other reason.