Study on Antiviral Therapy for HBeAg-positive Chronic Hepatitis B Patients Aged 1-16 Years

Inclusion Criteria: 1. Aged 1 to 16 years old. 2. Chronic Hepatitis B (CHB) patients or HBsAg positive \> 6 months patients who are line with the diagnostic criteria for chronic hepatitis B infection. 3. ALT:40～400 U/L. 4. HBeAg positive. 5. HBV DNA\>2×104IU/L. 6. Liver histology: G\<3. 7. Agree to sign the Informed Consent Form (Children aged 1-6 years may be signed by the guardian; children between the ages of 7 and 11 are in principle signed by the child and the guardian; those over the age of 12 must be signed by the child and the guardian) Exclusion Criteria: 1. white blood cell (WBC)\< 3.5×109/L，PLT\< 80×1012/L，Pt A\<60%，total bilirubin (TBIL)\>34umol/L，ALB\<35g/L，Cr\>133umol/L. 2. Combined with HAV、HCV、HDV、HEV or HIV-infected persons. 3. Patients combined with other causes of liver disease：alcoholic or non-alcoholic liver disease，thyroid disease，autoimmune liver disease，genetic metabolic liver disease，bile duct diseases，or Parasitic infection of hepatobiliary tract. 4. Patients with decompensated cirrhosis，including ascites. 5. Received the following medications（Immunosuppressant and Systemic cytotoxic drugs）in six months. 6. Patients who are allergy to IFNs and NAs; 7. Patients with other severe or active psychosomatic diseases （kidney, heart, lungs, vascular, neurological, digestive including history of pancreatitis, metabolic diseases including diabetes, thyroid and Adrenal disease, adrenal disease or tumor), Researchers believe which affect the treatment, evaluation or compliance of patients with the study plan. 8. Patients who unable to comply with the study arrangement judged by researcher.