A Study of ICP-192 in Patients With Advanced Solid Tumors

Major Inclusion Criteria Participants are eligible to be included in the study only if all of the following criteria apply: 1. Participate voluntarily, sign informed consent, and follow the study treatment plan and scheduled visits; 2. Phase I: Patients with histologically or cytologically confirmed unresectable or metastatic advanced malignant solid tumors who have progressed under standard treatment or recurred after or were intolerant to all standard treatment regimens, or have no standard treatment available; 3. Phase II: patients with histologically or cytologically confirmed unresectable or metastatic urothelial carcinoma or cholangiocarcinoma, who have progressed or recurred after or were intolerant to first-line chemotherapy, or have progressed/relapsed within 12 months after neoadjuvant /adjuvant chemotherapy; 4. Phase II: Existing test reports have confirmed the FGFR gene alteration or the central laboratory has detected the FGFR gene alteration. 5. Age ≥18 years old; 6. At least one measurable lesion according to the Response Evaluation Criteria of Solid Tumor, version 1.1 (RECIST 1.1); 7. ECOG performance status of 0-1; 8. Life expectancy for more than 3 months; Must have adequate organ function Major Exclusion Criteria Participants are excluded from the study if any of the following criteria apply: 1. Have previously been treated with selective pan-FGFR molecular inhibitors or antibody drugs, except for the FGFR4 selective inhibitors; 2. Within 2 weeks before the first dose of study drug, the subject's phosphate level continuing to exceed the ULN despite medical treatment; 3. Patients with clinically significant gastrointestinal dysfunction 4. Has known central nervous system metastases; 5. Has a history of or currently uncontrolled cardiovascular diseases 6. History of organ transplantation or a history of allogeneic hematopoietic stem cell transplantation; 7. Current evidence of corneal or retinal abnormalities that may increase eye toxicity; 8. Active hepatitis B virus active hepatitis C, or HIV infection; 9. Has not recovered from reversible toxicity of prior anti-tumor therapy 10. Pregnant or lactating women, as well as women with childbearing potential who are unwilling or unable to perform contraception from the screening to 6 months after the last study drug administration; and fertile men who are unwilling or unable to perform contraception from screening to 3months after the last study drug administration 11. Other conditions considered by the investigator to be inappropriate for participation in this study. NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.