A Study to Assess the Relative Bioavailability and Effect of Food on the Coated Granule Formulation of Mitapivat in Healthy Participants

Inclusion Criteria: * Body mass index between 18.0 and 32.0 kilograms per square meter (kg/m\^2), inclusive; * In good health, determined by no clinically significant findings from medical history, physical examination, 12-lead electrocardiogram (ECG), vital signs measurements, and clinical laboratory evaluations; * Females will not be pregnant or lactating, and females of childbearing potential and males will agree to use contraception; * Participant has no clinically significant history or presence of ECG findings as judged by the Investigator at Screening and Check-in. Exclusion Criteria: * Significant history or clinical manifestation of any metabolic, allergic, dermatological, hepatic, renal, hematological, pulmonary, cardiovascular, gastrointestinal, neurological, respiratory, endocrine, or psychiatric disorder, as determined by the Investigator; * History of significant hypersensitivity, intolerance, or allergy to any drug compound, food, including the 2 soft foods administered in this study, or other substance, unless approved by the Investigator; * History of stomach or intestinal surgery or resection including cholecystectomy that would potentially alter absorption and/or excretion of orally administered drugs (uncomplicated appendectomy and hernia repair will be allowed); * History of any malignancy with the exception of non-melanomatous skin cancer in situ, cervical carcinoma in situ, or breast carcinoma in situ; * Participant has liver function tests including alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase, and total bilirubin that are greater than the upper limit of normal at Screening or Check-in; * Participant has platelet count or hemoglobin and hematocrit values that are below the lower limit of normal at Screening or Check-in; * Confirmed (eg, original value and 2 consecutive repeat measurements) systolic blood pressure \>150 or \<90 millimeters of mercury (mmHg), diastolic blood pressure \>90 or \<50 mmHg, and pulse rate \>100 or \<45 beats per minute (bpm); * Confirmed QT interval corrected for heart rate using Fridericia's method (QTcF) \>450 milliseconds (msec) (male participants) or \>470 msec (female participants); * History of active alcoholism or drug/chemical abuse within 2 years prior to Check-in; * Alcohol consumption of \>21 units per week for males and \>14 units for females; * Positive urine drug screen at Screening or positive alcohol breath test result or positive urine drug screen at Check-in; * Positive hepatitis panel and/or positive human immunodeficiency virus test; * Participants with an active infection requiring systemic antimicrobial therapy, or with an active infection deemed clinically significant by the Investigator during Screening; * Participation in a clinical study involving administration of an investigational drug (new chemical entity) in the past 30 days or 5 half-lives prior to dosing (whichever is longer); * Participant has used any over-the-counter medications, including herbal or nutritional supplements, within 28 days (or 5 half-lives, whichever is longer) before the first dose of study drug until after the Follow up phone call; * Participant has used any prescription (excluding hormone replacement therapy and hormonal birth control) medications within 30 days (or 5 half-lives, whichever is longer) before the first dose of study drug until after the Follow up phone call; * Use of tobacco- or nicotine-containing products including cigarettes, snuff, nicotine patch, nicotine chewing gum, vaporizers, or inhalers, within 6 months prior to Screening until after the Follow up phone call, or positive cotinine at Screening or Check-in; * Participant must refrain from marijuana or cannabinol-containing products for 7 days before Screening until after the Follow up phone call; * Ingestion of poppy seed within 7 days prior to Check-in until after the Follow up phone call; * Participant has consumed grapefruit or grapefruit juice, Seville orange, or Seville orange containing products (eg, marmalade) within 7 days before the first dose of study drug until after the Follow up phone call; * Participant has consumed caffeine- or xanthine-containing products within 24 hours prior to first dose of study drug until after the Follow up phone call; * Participant has consumed vegetables from the mustard green family (eg, kale, broccoli, watercress, collard greens, kohlrabi, Brussels sprouts, and mustard), or charbroiled meats for 7 days prior to first dose of study drug until after the Follow-up phone call; * Participant is involved in strenuous activity or contact sports from 7 days before Check-in until after the Follow-up phone call; * Receipt of blood products within 2 months prior to Check-in; * Participant has donated blood or blood products \>450 milliliters (mL) within 30 days before the first dose of study drug; * Participant has a poor peripheral venous access; * Have previously completed or withdrawn from this study or any other study investigating mitapivat sulfate, and have previously received the mitapivat sulfate; * Participant has a history of allergy to sulfonamides (eg, co-trimoxazole antibiotic, silver sulfadiazine topical antibiotic for burn wounds) that has been characterized by acute hemolytic anemia, drug-induced liver injury, anaphylaxis, rash of erythema multiforme type, or Stevens-Johnson syndrome.