In this pilot study, the study evaluators will evaluate the ability of positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG PET) and the computed tomography (CT) perfusion scanner, individually and combined, to predict the effectiveness of anti-angiogenic treatment.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
14
IV application of F Dopa, 2 MBq per Kg, with a scout view (angle of view 90 °, 120 kV, 30 mAs), then an X-ray scan is performed for the attenuation correction ( 120 kV - 5mAs - pitch 0.531 - thickness // increment: 3.75mm//3.27mm -QAC filter - DFOV 25). PET acquisition: static in 3D mode for 20 minutes, 8 minutes after the injection of 18 F Dopa, the axial field of view is 25, the matrix in 256 x 256. After OSEM reconstruction 6 iterations and 24 subsets, with correction of attenuation and diffusion, then Gaussian filter of frequency 4, 47 contiguous axial sections of 3.26 mm are obtained.
Localization propeller without injection: 120kV - mA regulation (Noise Index 15) - pitch 0.969 - thickness // increment: 5mm // 5mm - Soft filter - Asir 60% - DFOV 25. Acquisition begins 5 seconds after the start of the injection of 60 ml of contrast product (VISIPAQUE) at 4 cc / second without (acquisition characteristics: 80 kV - 100 mAs -- thickness: 5mm // 8 images / rotation - STD filter - Asir 50% display field of view (DFOV) 25 - phase1: 5s then phase2 15s). Diagnostic quality CT: 120kV - Regulation of mA (Noise Index 15) - pitch 0.531 - thickness // increment: 1.25 // 0.625mm - Soft filter - Asir 60% - DFOV 25.
CHU de Nimes
Nîmes, France
Categorization of patients as responders or non-responders to treatment
Measured by MRI according to Response Assessment in Neuro-Oncology (RANO) criteria: Complete response/Partial response/stable/progression
Time frame: 2 months
Metabolic Tumor Volume
FDG PET
Time frame: Day 0
Metabolic Tumor Volume
FDG PET
Time frame: Day 14
Fixation Index
Maximum standard uptake value (SUV) and average SUV of the lesion divided by maximum SUV and average SUV of the striata
Time frame: Day 0
Fixation Index
Maximum standard uptake value (SUV) and average SUV of the lesion divided by maximum SUV and average SUV of the striata
Time frame: Day 14
permeability-surface area product
CT scan
Time frame: Day 0
permeability-surface area product
CT scan
Time frame: Day 14
cerebral blood flow
CT scan
Time frame: Day 0
cerebral blood flow
CT scan
Time frame: Day 14
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
If the examination is performed on the SIEMENS SKYRA 3T device: 32 channel head coil antenna, if on the PHILIPPS INGENIA 1.5 T device: DStream HeadSpine Coil antenna. The sequence begins with an axial, coronal and sagittal "Survey" topogram, lasting 1 minute. Then axial sequence T1, Axial T2 \*, Axial cerebral perfusion (Injection of gadolinium (0.1 mmol / kg, 5 cc / second), coronal T2, Axial T2 Flair, Axial DWI b100, Axial 3D T1 gadolinium
Normalized permeability-surface area product to healthy brain
CT scan
Time frame: Day 0
Normalized permeability-surface area product to healthy brain
CT scan
Time frame: Day 14
Normalized cerebral blood flow to healthy brain
CT scan
Time frame: Day 0
Normalized cerebral blood flow to healthy brain
CT scan
Time frame: Day 14
Inter-rater reproducibility of FDG PET
LIN intraclass correlation coefficient
Time frame: End of study (September 2022)
Inter-rater reproducibility of CT scan
LIN intraclass correlation coefficient
Time frame: End of study (September 2022)