Safety and Efficacy of Human Umbilical Cord Blood Plasma Infusion for Age-Related Cognitive Decline

Inclusion Criteria: 1. Age 65-85 years old 2. Evidence of cognitive decline on neuro-cognitive testing 3. Able to participate in research trial for 12 months 4. Women must have documented menopause or infertility determination 5. Ability to receive intravenous infusions 6. Patient or legally authorized representative able to sign informed consent Exclusion Criteria: 1. Patients receiving any other investigational biologics or drugs 2. History of transfusion reaction 3. Dementia related to specific pathology (Alzheimer's Disease, Alcohol-related, etc.) 4. Inability to participate in cognitive or performance testing 5. History of cancer in the last 5 years 6. History of infectious disease within the previous 12 months 7. Severe kidney (eGFR\< 30) and heart failure (Class III/IV) 8. History of Human Immunodeficiency Virus Infection 9. History of Hepatitis B, or C 10. History of immunosuppressive therapy 11. History of organ transplantation 12. Difficulty of obtaining peripheral venous access 13. Allergy to histamine blockers 14. Inability to participate in the clinical trial at any data collection and end points \-