The main purposes of this study include: Looking at the way the body absorbs, distributes, and gets rid of 89Zr-DFO-REGN3767 Finding the best dose amount of 89Zr-DFO-REGN3767 Finding the best time for PET scanning after injection of 89Zr-DFO-REGN3767
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
7
89Zr-DFO-REGN3767 is comprised of the anti-LAG-3 antibody, REGN3767 labeled with the positron-emitter zirconium-89 (89Zr) through the chelator-linker DFO. REGN3767 is an investigational monoclonal antibody that target LAG-3 receptors.
A PET/CT scan extending from top of skull to feet will be performed to determine the biodistribution. Part A patients will be imaged at three time points post-injection to allow for selection of optimal imaging time and dosimetry determination. For these patients, top of skull to feet scans will be acquired: * Within one to four hours following injection of tracer on Day 1 * 24-72 hours post-injection (Day 2-4) * 20-168 hours post-injection (once during days 5-7)
Memorial Sloan Kettering Cancer Center
New York, New York, United States
Biodistribution of 89Zr-DFO-REGN3767
A PET/CT scan extending from top of skull to feet will be performed to determine the biodistribution of 89Zr-DFO-REGN3767
Time frame: 2 years
Optimal 89Zr-DFO-REGN3767 mass dose for tumor targeting
Determine the optimal 89Zr-DFO-REGN3767 mass dose for tumor targeting
Time frame: 2 years
Optimal time for imaging and tumor uptake post 89Zr-DFO-REGN3767 administration
Determine the optimal time for imaging and tumor uptake post 89Zr-DFO-REGN3767 administration
Time frame: 2 years
Tumor lesion uptake of 89Zr-DFO-REGN3767 and correlate with LAG-3 expression by IHC
Evaluate tumor lesion uptake of 89Zr-DFO-REGN3767 and correlate with LAG-3 expression by IHC in tumors will be compared descriptively with other biomarkers of tumor immune environment characterized in biopsies, such as quantitation of IHC score (LAG-3 and / or other immune cell markers), or other biomarker measures.
Time frame: 2 years
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