CTC in Lung Caner Patients With Bone Metastases

Shanghai 6th People's Hospital160 enrolled

Overview

1. Evaluate the feasibility of single cell sequencing technology based on three-dimensional bionic capture network; 2. To build a risk prediction model of bone related events based on single cell sequencing; 3. To verify the risk prediction model of bone related events by single cell sequencing; 4. To verify the comprehensive treatment of non-small cell lung cancer ( NSCLC) bone metastases.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

160

Conditions

Lung Cancer Bone Metastases Single Cell Sequencing Technology

Interventions

model treatmentOTHER

the treatment decisions were decided by Machine Learning （ML） model in model treatment group

routine treatmentOTHER

the treatment decisions were decided by multi-disciplinary team （MDT）

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. age 18-75 years 2. pathology-proven diagnosis of lung cancer and radiographical/pathological evidence of BM 3. no previous treatment for BM 4. good general condition (Eastern Cooperative Oncology Group, ECOG Performance scores: 0-2) with an estimated survival time \> 3 months. Exclusion Criteria: \-

Locations (1)

Shanghai Sixth People'S Hospital

Shanghai, Other (Non U.s.), China

RECRUITING

Outcomes

Primary Outcomes

SREs（Skeletal related events）

occurance of SREs，including bone pain, pathological fractures, spinal cord compression, hypercalcemia, and the need for surgery or radiotherapy

Time frame: 1 year

Data from ClinicalTrials.gov

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