DNA methylation biomarker for diagnosis of cholangiocarcinoma in patients with bile duct stricture has high sensitivity and specificity compared with cytology from the brush specimens
The methylation of HOXA1, NEUROG1 were used to determine cholangiocarcinoma from brushed biliary samples. However, the sensitivity and specificity of this test for cholangiocarcinoma is still required.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Enrollment
67
Brushed biliary samples from a known case of benign biliary stricture were sent for DNA Methylation Biomarker test and cell cytology
Brushed biliary samples from a known case of cholangiocarcinoma were sent for DNA Methylation Biomarker test and cell cytology
Faculty of medicine, Siriraj hospital
Bangkok Noi, Bangkok, Thailand
The methylation of HOXA1, NEUROG1 were determined in brushed biliary samples from patients with CCAs compared to those of nonmalignant bile duct stricture
Methylation index of biliary brush samples were analyzed.
Time frame: 2 weeks
Sensitivity, specificity of DNA methylation for diagnosis of cholangiocarcinoma
Diagnostic accuracy of methylation index for diagnosis of cholangiocarcinoma was analyzed.
Time frame: 2 weeks
To compared sensitivity, specificity of DNA methylation with routine cytology of biliary brushed samples
Diagnostic accuracy of methylation index was compared to routine brush cytology.
Time frame: 2 weeks
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