Identification of Relevant Biological, Imaging, Mobility and Clinical Markers for Clinical Research in Sarcopenia

Inclusion Criteria: Participants will have the following inclusion criteria: * Male with age ≥ 65 years * Body Mass Index: 20 \< BMI \< 35 kg/m2 * Able to understand and having signed an informed consent * Able to follow the trial procedures Sarcopenic population: diagnosed sarcopenia following definition of the EWGSOP2: * Muscle strength assessed by the handgrip test \<27 kg for male * Skeletal muscle mass index (Appendicular lean muscle mass) assessed by DXA \<7.0 kg/m2 Non-sarcopenic population: adapted from the EWGSOP2: * Muscle strength assessed by the handgrip test ≥ 27 kg * Skeletal muscle mass index (Appendicular lean muscle mass) assessed by DXA ≥ 7.0 kg/m2 Exclusion Criteria: Participants will have the following exclusion criteria: * Any clinically significant levels of the safety parameters (Creatine Kinase (CK), activated Partial Thromboplastin Time (aPTT), Prothrombin Time and International Normalized Ratio (PT/INR)) * Any severe, uncontrolled and limiting diseases (e.g. systemic inflammation, infectious diseases, active cancer, neurodegenerative disorders, diabetes) left to the investigator's discretion * Bed resting for more than 10 days during the 3 months preceding the recruitment * Immobilization of the lower limb, lasting more than one week during the 3 months preceding recruitment * Medical treatment with anticoagulant, insulin, immunosuppressant, long-term corticosteroid (over 7.5 mg prednisone or its equivalent) * Severe incapacity (class IV Steinbrocker Functional Classification - Appendix 2) * Any treatment that may affect physical performance, muscle function, disrupts study measures or impairs the understanding of consent * Known acute or severe renal insufficiency (glomerular filtration rate \< 30 mL/min/1.73m2) * Cushing' syndrome * Known cachexia * Currently participating or having participated in another therapeutic clinical trial in the three previous months * Under guardianship or judicial protection