Obesity in Sleep Medicine - Focusing on OHS Phenotypes

Wissenschaftliches Institut Bethanien e.V82 enrolled

Overview

This study focuses on a comprehensive examination of obese patients with sleep-related breathing disorders including patients with OSA, sleep hypoventilation and OHS. The aim of this study is to (1) evaluate characteristics of and differences between severity levels of obesity-related breathing disorders, (2) discuss pathophysiological variables associated with hypoventilation during sleep or at daytime and (3) find functional parameters indicating sleep hypoventilation.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Obesity Hypoventilation Syndrome (OHS)

Interventions

Sleep StudyDIAGNOSTIC_TEST

Full-night attended in-lab polysomnography with accompanying transcutaneous capnometry

Pulmonary Function TestDIAGNOSTIC_TEST

Bodyplethysmographic assessment

Hypercapnic ventilatory responseDIAGNOSTIC_TEST

Measurement of hypercapnic ventilatory response based on the method described by Read in 1967, using a rebreathing bag

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥18 years * BMI ≥ 30 kg/m² * Indication for sleep lab admission or indication for BiLevel or non-invasive ventilation therapy initiation due to existing hypoventilation/OHS Exclusion Criteria: * Age \<18 years * Pregnancy, Lactation * Any medical, psychological or other condition impairing the patient's ability to provide informed consent. * Missing informed consent * Participation in another clinical study

Locations (1)

Institut für Pneumologie an der Universität zu Köln / Wissenschaftliches Institut Bethanien für Pneumologie e.V.

Solingen, North Rhine-Westphalia, Germany

Outcomes

Primary Outcomes

Hypercapnic ventilatory response

Time frame: Within 48 hours of sleep lab admission

Data from ClinicalTrials.gov

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