Alzheimer's disease (AD) is a neurodegenerative disorder affecting almost 6% of the world's population over the age of 65. This disease, in its most typical sporadic form, is characterized by an episodic memory impairment linked to a deficit in consolidation. Many studies indicate that sleep promotes this consolidation stage during the deep slow sleep stage by facilitating the transfer of information between the hippocampus and the neocortex. A method of acoustic brain stimulation at night by pink noises has been recently developed and has shown its effectiveness in strengthening memory consolidation in healthy volunteers. Actually, there is no study observing the effect of this new stimulation method on populations with neurodegenerative pathologies, in particular in AD for which this technique could potentially become a therapeutic option. The hypothesis is that of a strengthening of the memory consolidation capacities in subjects with AD as has been shown in healthy subjects.
Alzheimer's disease (AD) is a neurodegenerative disorder affecting almost 6% of the world's population over the age of 65. This disease, in its most typical sporadic form, is characterized by an episodic memory impairment linked to a deficit in consolidation. Many studies indicate that sleep promotes this consolidation stage during the deep slow sleep stage by facilitating the transfer of information between the hippocampus and the neocortex. A method of acoustic brain stimulation at night by pink noises has been recently developed and has shown its effectiveness in strengthening memory consolidation in healthy volunteers. Actually, there is no study observing the effect of this new stimulation method on populations with neurodegenerative pathologies, in particular in AD for which this technique could potentially become a therapeutic option. The hypothesis is that of a strengthening of the memory consolidation capacities in subjects with AD as has been shown in healthy subjects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
30
acoustic stimulation
acoustic stimulation
University Hospital of Tours
Tours, France
RECRUITINGdifference between morning and eve of the number of reminders found between the "ON-stimulation" condition and the "OFF-stimulation" condition, on the memory task of word matching.
gross variation of the difference between morning and eve of the number of reminders found between the "ON-stimulation" condition and the "OFF-stimulation" condition, on the memory task of word matching.
Time frame: Day 7
difference between morning and eve of the number of reminders found between the "ON-stimulation" condition and the "OFF-stimulation" condition, on the memory task of word matching.
gross variation of the difference between morning and eve of the number of reminders found between the "ON-stimulation" condition and the "OFF-stimulation" condition, on the memory task of word matching.
Time frame: Day 8
difference between morning and eve of the number of reminders found between the "ON-stimulation" condition and the "OFF-stimulation" condition, on the memory task of word matching.
gross variation of the difference between morning and eve of the number of reminders found between the "ON-stimulation" condition and the "OFF-stimulation" condition, on the memory task of word matching.
Time frame: Day 14
difference between morning and eve of the number of reminders found between the "ON-stimulation" condition and the "OFF-stimulation" condition, on the memory task of word matching.
gross variation of the difference between morning and eve of the number of reminders found between the "ON-stimulation" condition and the "OFF-stimulation" condition, on the memory task of word matching.
Time frame: Day 15
Number of reminders found between the "ON-stimulation" condition and the "OFF-stimulation" condition, on the ecological memory task.
gross variation of the difference between morning and eve of the number of reminders found between the "ON-stimulation" condition and the "OFF-stimulation" condition, on the ecological memory task.
Time frame: Day 7
Number of reminders found between the "ON-stimulation" condition and the "OFF-stimulation" condition, on the ecological memory task.
gross variation of the difference between morning and eve of the number of reminders found between the "ON-stimulation" condition and the "OFF-stimulation" condition, on the ecological memory task.
Time frame: Day 8
Number of reminders found between the "ON-stimulation" condition and the "OFF-stimulation" condition, on the ecological memory task.
gross variation of the difference between morning and eve of the number of reminders found between the "ON-stimulation" condition and the "OFF-stimulation" condition, on the ecological memory task.
Time frame: Day 14
Number of reminders found between the "ON-stimulation" condition and the "OFF-stimulation" condition, on the ecological memory task.
gross variation of the difference between morning and eve of the number of reminders found between the "ON-stimulation" condition and the "OFF-stimulation" condition, on the ecological memory task.
Time frame: Day 15
The memory complaint for Mc Nair's Questionnaire
score from 0 to 156.156 control of a bad score. The variation between J0 and J15 will be studied.
Time frame: Baseline
Psychoaffective aspects (Depression) for MADRS (Montgomery Asberg Depression Rating Scale)
score from 0 to 60.60 control of a bad score. The variation between J0 and J15 will be studied.
Time frame: Baseline
Psychoaffective aspects (Anxiety) for HAMA (Hamilton Anxiety)
score from 0 to 56.56 control of a bad score. The variation between J0 and J15 will be studied.
Time frame: Baseline
Quality of sleep for Pittsburgh Index (PSQI)
It is more an index of tolerance than efficiency. If the score is higher, the tolerance is lower.
Time frame: Baseline
The memory complaint for Mc Nair's Questionnaire
score from 0 to 156.156 control of a bad score. The variation between J0 and J15 will be studied.
Time frame: Day 15
Psychoaffective aspects (Depression) for MADRS (Montgomery Asberg Depression Rating Scale)
score from 0 to 60.60 control of a bad score. The variation between J0 and J15 will be studied.
Time frame: Day 15
Psychoaffective aspects (Anxiety) for HAMA (Hamilton Anxiety)
score from 0 to 56.56 control of a bad score. The variation between J0 and J15 will be studied.
Time frame: Day 15
Quality of sleep for Pittsburgh Index (PSQI)
It is more an index of tolerance than efficiency. If the score is higher, the tolerance is lower.
Time frame: Day 15
amplitude of slow waves in deep slow sleep between the "ON-stimulation" condition and the "OFF-stimulation" condition
gross variation in the amplitude of slow waves in deep slow sleep between the "ON-stimulation" condition and the "OFF-stimulation" condition, on an ambulatory EEG device
Time frame: Day 7
amplitude of slow waves in deep slow sleep between the "ON-stimulation" condition and the "OFF-stimulation" condition
gross variation in the amplitude of slow waves in deep slow sleep between the "ON-stimulation" condition and the "OFF-stimulation" condition, on an ambulatory EEG device
Time frame: Day 8
amplitude of slow waves in deep slow sleep between the "ON-stimulation" condition and the "OFF-stimulation" condition
gross variation in the amplitude of slow waves in deep slow sleep between the "ON-stimulation" condition and the "OFF-stimulation" condition, on an ambulatory EEG device
Time frame: Day 14
amplitude of slow waves in deep slow sleep between the "ON-stimulation" condition and the "OFF-stimulation" condition
gross variation in the amplitude of slow waves in deep slow sleep between the "ON-stimulation" condition and the "OFF-stimulation" condition, on an ambulatory EEG device
Time frame: Day 15
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