Obesity is now becoming a worldwide serious problem. Obesity is associated with a spectrum of severe diseases, including diabetes, cardiovascular diseases, and cancers. Lipocalin 2 (LCN2), also known as neutrophil gelatinase associated lipocalin (NGAL), is a member of the lipocalin family. Due to its upregulated expression in infection, LCN2 is originally considered to be a key regulator of immune response. Subsequent investigations revealed that LCN2 is expressed in many tissues and is related to a variety of diseases, including obesity. LCN2 was reported to be increased in obesity individuals. Thus, the investigators decide to investigate the relationship between LCN2 and obesity.
Study Type
OBSERVATIONAL
Enrollment
500
bariatric surgery
Department of Endocrinology, Shanghai Tenth People's Hospital
Shanghai, Shanghai Municipality, China
RECRUITINGLCN2 level
Lipocalin 2 level
Time frame: 2019-2024
meet the criteria of metabolism in the 2017 Chinese guideline
Abdominal obesity (or central obesity), male abdominal circumference ≥90cm, female abdominal circumference ≥85cm;
Time frame: 2019-2024
FBG
patients with fasting blood glucose 6.1mmol/l or more
Time frame: 2019-2024
PBG
patients with 2 hour blood glucose 7.8mmol/l or more
Time frame: 2019-2024
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