Food Supplementation With Eufortyn Colesterolo Plus for LDL Modulation in Subjects With Polygenic Hypercholesterolemia

Inclusion Criteria: * Subjects agree to participate in the study and having dated and signed the informed consent form. * Subjects who have the capability to communicate, to make themselves understood, and to comply with the study's requirements. * Male or female aged ≥ 18 years and ≤ 70 years old. * LDL-Cholesterol plasma levels \>115 mg/dL and \< 190 mg/dL. * TG\<400 mg/dL. * Subjects who, according to the SCORE charts, have a low or moderate cardiovascular risk (defined as a total cardiovascular risk \< 5%) and for whom, according to ESC/EAS guidelines 2019, the intervention strategy does not require a pharmacological lipid lowering intervention. Exclusion Criteria: * Subjects already affected by cardiovascular diseases (secondary prevention) or with estimated 10 years cardiovascular disease risk\> 5%; * Obesity (BMI\>30 kg/m2) or diabetes mellitus; * Assumption of lipid lowering drugs or food supplements, or drugs potentially affecting the lipid metabolism; * Antihypertensive treatment not stabilized since at least 3 months; * Anticoagulants therapy * Uncontrolled hypertension (systolic blood pressure\> 190 mmHg or diastolic arterial pressure\> 100 mmHg); * Known current thyroid, gastrointestinal or hepatobiliary diseases; * Any medical or surgical condition that would limit the patient adhesion to the study protocol; * Abuse of alcohol or drugs (current or previous); * History of malignant neoplasia in the 5 years prior to enrolment in the study; * History or clinical evidence of inflammatory disease such as severe arthritis, systemic lupus erythematosus or chronic inflammatory diseases or current therapy with immunosuppressive agents or long-term glucocorticoids; * History or clinical evidence of any significant concomitant disease that could compromise the safety of the subject or the possibility of completing the study; * Known previous intolerance to one component of the tested nutraceuticals * Women in fertile age not using consolidated contraceptive methods * Pregnancy and Breastfeeding.