An International Randomized Trial of Additional Treatments for COVID-19 in Hospitalized Patients Who Are All Receiving the Local Standard of Care - WHO-SOLIDARITY-GERMANY

Inclusion Criteria: * Patients 18 years and older * Current SARS-CoV-2 infection * Admitted to the hospital ward or the ICU due to COVID-19 * SpO2 \<= 94% on room air OR oxygen demand OR breathing support * Written informed consent obtained Exclusion Criteria: * Patient's non-consent or inability to informed consent * Pregnant or breastfeeding women. * Subjects pretreated with one of the study drugs in the past 29 days * Anticipated transfer within 72 hours to a non-study hospital * Severe co-morbidity with life expectancy \< 3 months * AST or ALT \> 5 times the upper limit of normal * Stage 4 severe chronic kidney disease or requiring dialysis * Contraindications and known intolerance to any of the study drugs * Subjects participating in a potentially confounding drug or device trial * Any reason why the patient should not participate (investigator's opinion)