Quantitative Ultrasound With Liver Incytes for Evaluation of Non-Alcoholic Fatty Liver Disease

Inclusion Criteria: 1. Adults aged 21 years or older 2. Suspected NAFLD or NASH with plans to undergo standard of care liver biopsy 3. History of biopsy proven NAFLD or NASH within 6 months prior to enrollment 4. Planned liver biopsy for evaluation of NAFLD within 6 months of enrollment 5. Ability to provide informed consent Exclusion Criteria: 1. Fasting for less than three hours prior to the scan 2. Subject is a pregnant or lactating female 3. Subject with current, significant alcohol consumption or history of significant alcohol consumption for a period of more than 3 consecutive months any time within 1 year prior to screening. Significant alcohol consumption is defined as more than 20 gram per day in females and more than 30 grams per day in males, on average (a standard drink in the US is considered to be 14 grams of alcohol). 4. Subject is unable to reliably quantify alcohol consumption based upon local study physician judgment. 5. Subject uses drugs historically associated with NAFLD (amiodarone, methotrexate, systemic glucocorticoids, tetracyclines, tamoxifen, estrogens at doses greater than those used for hormone replacement, anabolic steroids, valproic acid, and other known hepatotoxins) for more than 2 weeks in the year prior to screening 6. Subject with history of cirrhosis or clinical evidence of hepatic decompensation as defined by the presence of any of the following abnormalities at screening 1. Serum albumin less than 3.5 grams/deciliter (g/dL). 2. INR greater than 1.5. 3. Direct bilirubin greater than 1.3 milligrams per deciliter (mg/dL). 7. Subject has a history of bleeding esophageal varices, ascites or hepatic encephalopathy 8. Subject has history of other forms of chronic liver diseases such as viral hepatitis, autoimmune hepatitis, cholestatic liver disease (primary biliary cirrhosis or primary sclerosing cholangitis). 9. Subject with active substance abuse 10. Acute hepatitis defined as AST/ALT \> 500 U/L 11. Patients with a pacemaker or defibrillator 12. Ascites