A Prospective, Open Label, Multicenter Trial for Evaluating the Efficacy of Treating and Managing Wounds in Elderly Population in Specialized Nursing Facilities Using RD1

Inclusion Criteria: * Subject is ≥18 years of age * Patient with a wound deemed suitable for treatment with RD1 * Ulcer free of clinical signs of infection. * Post-debridement, ulcer free of necrotic tissue. * For foot ulcers, Subject has adequate vascular perfusion of the affected limb, as defined by - Ankle-Brachial Index (ABI) ≥ 0.65 and ≤ 1.2 * HbA1c ≤ 12.0% (diabetic patients) * Subject or legal authorized representative must be willing to comply with the protocol including having blood drawn to create the RD1. * Female subjects who are capable of conceiving must use an acceptable form of contraception in order to participate in the study (acceptable forms of contraception include condoms for males and contraceptive pills or IUDs for women). Exclusion Criteria: * If ulcer area decreases by ≥ 30% during the initial 2-week screening (± 2 days) and standard of care phase, or if the ulcer area increases ≥ 30%, * Presence of active underlying osteomyelitis. * Patient with a proven sepsis established by a blood culture in the past 2 weeks, or confirmed active infection likely to interfere with trial, such as urine tract infection * Known malignancy in the reference wound bed or margins of the wound * Exposure of blood vessels or organs at the base of the reference wound * History of alcohol or substance abuse, within the previous 2 months * Subject has participated in another clinical trial involving a device or a systemically administered investigational study drug or treatment within 30 days of day 0 visit. * Subject is currently receiving (i.e., within the past 30 days) or scheduled to receive a medication or treatment which, in the opinion of the Investigator, is known to interfere with, or affect the rate and quality of, wound healing (e.g., systemic steroids (more than 10mg per day), immunosuppressive therapy, autoimmune disease therapy, cytostatic therapy within the past 12 months, dialysis, radiation therapy to the ulcer area, vascular surgery, angioplasty or thrombolysis). * Subject has been treated with wound dressings that include growth factors, engineered tissues or skin substitutes within 30 days of randomization or is scheduled to receive during the study. * Subject has been treated with hyperbaric oxygen within 5 days of screening or is scheduled to receive during the study. * Wound on a patient who has a life expectancy of less than 6 months. * Cannot withdraw blood in the required amount technically. * Known coagulation problems, abnormal thrombocytes level or if heparin is given intravenously. Patients who are taking orally Coumadin, Aspirin, or Plavix (clopidogrel) will not be excluded. * Hemoglobin anemia (\< 9 g/dL). * Subject has an infectious disease, such as Acquired Immune Deficiency Disease (AIDS) or HIV, Hepatitis C, Hepatitis B, Human T-lymphotropic virus or Syphilis * Women who are pregnant or currently breast feeding.