This study evaluates the effect of L. reuteri ATCC PTA 6475 supplementation on testosterone in men.
The probiotic Lactobacillus reuteri ATCC PTA 6475 has been shown to modulate testosterone levels in mice. It is not known if these effects are seen in humans and this trial is intended to study this. The aim of this study is to investigate if L. reuteri ATCC PTA 6475 will effect blood testosterone levels in in healthy male subjects 50-65 years of age.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Enrollment
60
L.reuteri high or low dose with vitamin D3 compared to vitamin D3 only
Department of Health & Society, Malmö University
Malmö, Skåne County, Sweden
Concentration of total testosterone
Change in total testosterone concentration over time
Time frame: Baseline, 6 weeks, 12 weeks
Free testosterone index
Change in Free testosterone index (100x(Testosterone/SHBG) over time
Time frame: Baseline, 6 weeks, 12 weeks
Percentage of hematokrit
Change in Hematokrit over time
Time frame: Baseline, 6 weeks, 12 weeks
Number of adverse events
Adverse event from administration of first dose until 12 weeks
Time frame: Continously 12 weeks
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