Critically ill patients requiring intensive care suffer to a large extent from cognitive deficits involving higher brain functions that primarily affect memory, learning and the ability to concentrate. While the background to this effect is not fully understood, there are growing evidence to support mechanisms related to neuro inflammation and changes in blood flow with concomitant ischemic brain damage. Patients with covid-19 often suffer from severe inflammatory activity with an increased risk of coagulation abnormalities and brain damage. Covid-19 patients requiring intensive care develope more severe impairment of neurological and cognitive function than critically ill intensive care patients who have not covid-19. This project therefore aims to map the link between inflammation, immunology and coagulation systems as well as biochemical and structural changes in the brain with cognitive effects in patients in intensive care for covid-19.
Study Type
OBSERVATIONAL
Enrollment
100
Karolinska Universitetssjukhuset Solna
Stockholm, Sweden
The association between changes in blood biomarkers for inflammation and the presence of neuroradiologically verified brain injury and neurocognitive disorder
Time frame: Up to 12 months
The association between changes in blood biomarkers for nerve cell damage and the presence of neuroradiologically verified brain injury and neurocognitive disorder
Time frame: Up to 12 months
The association between changes in blood biomarkers for neurodegeneration and the presence of neuroradiologically verified brain injury and neurocognitive disorder
Time frame: Up to 12 months
The association between changes in coagulation factors and the presence of neuroradiologically verified brain injury and / or neurocognitive disorder
Time frame: Up to 12 months
The association between changes in coagulation ability (ROTEM analysis - rotational thromboelastometry) and the presence of neuroradiologically verified brain injury and / or neurocognitive disorder
Time frame: Up to 12 months
The association between changes in inflammatory biomarkers and the presence of neuroradiologically verified brain injury and / or neurocognitive disorder
Time frame: Up to 12 month
Blood biomarker changes of inflammation impact
Markers of inflammation impact - in relation to cerebrospinal fluid changes .
Time frame: Up to 3 months
Blood biomarker changes of neurological impact
Markers of neurological impact - in relation to cerebrospinal fluid changes .
Time frame: Up to 3 months
Neuroradiological changes
Neurological impact in relation to cerebrospinal fluid changes
Time frame: Up to 3 months
Clinical course - Pulmonary gas exchange
in relation to cerebrospinal fluid changes/blood
Time frame: Up to 3 months
Clinical course - Lung function recording
in relation to cerebrospinal fluid changes/blood
Time frame: Up to 3 months
Patient characteristics
Patient ICU care data - in relation to cerebrospinal fluid changes
Time frame: Up to 3 months
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