Poor management of post-operative acute pain can contribute to medical complications including pneumonia, deep vein thrombosis, infection and delayed healing, as well as the development of chronic. In contrast, appropriate pain control is capable of reducing the postoperative complications, preventing the development of chronic pain, and improving the quality of life. The workloads of medical staffs and health care cost are subsequently decreased. Recently, a lot of analgesic methods have been developed and used in clinical practice, such as patient-controlled analgesia, ultrasound-guided long-term analgesia and multimodal analgesia. This study is aimed to investigate the effect of dinalbuphine sebacate, a long-acting analgesic, in postoperative pain management. This real world data can serve as a reference toward high health care quality.
This is a prospective, observational, cohort study. Patients undergoing elective surgery will be invited to the study. The written informed consent will be obtained prior to participation. Demographic data, underlying condition, surgical procedures, consumption of anesthetics and analgesics, analgesic methods, postoperative complications, pain intensity and life quality will be collected from medical history and by questionnaires.
Study Type
OBSERVATIONAL
Enrollment
634
After anesthesia, extended-release dinalbuphine sebacate (ERDS) is injected into gluteus maximus with ultrasound guidance.
China Medical University Hsinchu Hospital
Hsinchu, Taiwan
Postoperative pain intensity (numerical rating scale)
Numerical rating scale (NRS) is used to assess pain intensity from surgical day (Day 0) to five days after surgery (Day 5). NRS is a 11-point scale which labeled from zero (no pain) to ten (worst pain).
Time frame: From Day 0 to Day 5
Consumption of anesthetics
Amounts of medicines used during surgery are all analyzed, especially the ones related to analgesia.
Time frame: From Day 0 to Day 5
Consumption of analgesics
Amounts of opioids are converted into morphine equivalents. Amounts of NSAIDs are calculated separately.
Time frame: From Day 0 to Day 5
Adverse events
Percentage of the population suffering from postoperative adverse events are analyzed, especially the ones related to analgesics.
Time frame: From Day 0 to Day 5
EQ-5D-5L score
EQ-5D-5L questionnaire is used to assess patients' life quality. Patients are asked to fill in the questionnaire prior to surgery, before discharge and/or three months after surgery.
Time frame: Within 16 weeks after surgery
Patient satisfaction
Before discharge, patients are asked to rate satisfaction toward postoperative pain management on a 5-point scale: very satisfied, satisfied, uncertain, dissatisfied, very dissatisfied.
Time frame: Within 5 days after surgery
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