Coronary Artery Disease (CAD) in Patients HIV-infected

Hôpital Européen Marseille60 enrolled

Overview

HIV-infected patients with intermediate-high risk have a high prevalence of CAD and a substantial proportion of obstructive CAD. Degree of stenosis is associated with immunoactivation (lymphocyte and monocyte) and microbial translocation

Study Type

OBSERVATIONAL

Enrollment

Conditions

HIV Infections

Interventions

coronary computed tomographic angiographic (CCTA)OTHER

x-ray examination with contrast by a 64-slice CT coronary angiography.

Eligibility

Sex: ALLMin age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: HIV-infected patients \>= 45 years with 2 or more CV risk factors currently on ART HIV-RNA \< 50 copies \>= 12 months (one blip allowed) Asymptomatic regarding cardiac symptoms (chest pain, syncope, dyspnea) Stable ART for more than 6 months Exclusion Criteria: * Sign of coronary pathology (chest pain, syncope, dyspnea). * ATCD of allergy to IV contrast agents * Chronic inflammatory disease other than HIV * Subject to a measure for the protection of justice

Locations (1)

BENNANI

Marseille, France

RECRUITING

Outcomes

Primary Outcomes

correlation between a particular profile of immune activation in patients HIV under treatment presenting cardiovascular risk factors and the presence of coronary atheromatous plaques

Assessment of the prevalence of obstructive coronary artery disease in patients infected with HIV and asymptomatic with a 64-slice CT coronary angiography.

Time frame: 24 months

Secondary Outcomes

Identify the bacterial populations constituting the intestinal microbiota in patients infected with HIV and look for a microbiotic signature in patients with subclinical atherothrombosis.

microbial translocation (16S DNA)

Time frame: 24 months

Data from ClinicalTrials.gov

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